Overview of Clinical Research | <span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Ciclesonide is a Glucocorticoid receptor agonist. The US FDA approved IND application for ciclesonide in COVID-2019 infections in 2020.</span></span></span>
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IUPAC Name | [2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate |
InChI | InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24?,26-,27-,29?,30-,31-,32+/m0/s1 |
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2: Barthwal MS, Meshram S. A randomized, double-blind study comparing the efficacy and safety of a combination of formoterol and ciclesonide with ciclesonide alone in asthma subjects with moderate-to-severe airflow limitation. Lung India. 2017 Jan-Feb;34(1):111-112. doi: 10.4103/0970-2113.197102. PubMed PMID: 28144080; PubMed Central PMCID: PMC5234188.<br />
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4: Mukker JK, Singh RS, Derendorf H. Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids. J Pharm Sci. 2016 Sep;105(9):2509-14. doi: 10.1016/j.xphs.2016.05.004. Epub 2016 Jun 21. PubMed PMID: 27339407.<br />
5: Liddell BS, Oberlin JM, Hsu DP. Inhaled corticosteroid related adrenal suppression detected by poor growth and reversed with ciclesonide. J Asthma. 2017 Jan 2;54(1):99-104. doi: 10.1080/02770903.2016.1196370. Epub 2016 Jun 10. PubMed PMID: 27284755.<br />
6: Salvi SS, Vaidya AJ, Kodgule RR, Gogtay JA. A randomized, double-blind study comparing the efficacy and safety of a combination of formoterol and ciclesonide with ciclesonide alone in asthma subjects with moderate-to-severe airflow limitation. Lung India. 2016 May-Jun;33(3):272-7. doi: 10.4103/0970-2113.180803. PubMed PMID: 27185990; PubMed Central PMCID: PMC4857562.<br />
7: Mandaliya PH, Kennedy B, van Asperen P, Robinson PD. Ciclesonide-induced bronchospasm: an important but preventable side effect. Med J Aust. 2015 Sep 7;203(5):233-3e.1. PubMed PMID: 26852062.
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