Ciclesonide- CAS 126544-47-6

Ciclesonide (CAS 126544-47-6) is an inhaled corticosteroids, used to ameliorate symptoms of airway inflammatory diseases, such as asthma, allergic rhinitis, and chronic obstructive pulmonary disease. Ciclesonide is a corticosteroid prodrug that is converted to its active form, desisobutyryl-CIC. Des-CIC is a glucocorticoid receptor agonist.

Catalog Number: A000036

CAS Number: 126544-47-6

PubChem Substance ID:355038491

Molecular Formula: C32H44O7

Molecular Weight:540.7

Purity: ≥95%

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Synonym

SynonymsCiclesonide, Alvesco, Omnaris, RPR251526, Zetonna

Property

Molecular Formula: C32H44O7
Molecular Weight540.7
Target:Glucocorticoid Receptor
Solubility>15.8mg/mL in DMSO
Purity≥95%
StorageStore at -20°C
Overview of Clinical Research<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Ciclesonide is a&nbsp;Glucocorticoid receptor agonist.&nbsp;The US FDA approved IND application for ciclesonide in COVID-2019 infections in 2020.</span></span></span>

Computed Descriptor

IUPAC Name[2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate
InChIInChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24?,26-,27-,29?,30-,31-,32+/m0/s1
InChIKeyLUKZNWIVRBCLON-ROPSEAAASA-N
SMILESO=C1C=C[[email protected]@]2(C)C(CC[[email protected]]3([H])[[email protected]]2([H])[[email protected]@H](O)C[[email protected]@]4(C)[[email protected]@]3([H])C[[email protected]]5([H])[[email protected]@]4(C(COC(C(C)C)=O)=O)O[[email protected]](C6CCCCC6)O5)=C1