Diflorasone

• CAT Number: R049414
• CAS Number: 2557-49-5
• Molecular Formula: C22H28F2O5
• Molecular Weight: 410.458
• Purity: ≥95%
• Storage: Store at -20C
• IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
• InChIKey: WXURHACBFYSXBI-XHIJKXOTSA-N
• SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Difluoperasone (Cat. No: R049414) is a corticosteroid preparation with anti-inflammatory, anti-pruritus, immunosuppressive, and vasoconstrictive effects. The pharmacological effects of diflorasone are similar to those of betamethasone and its derivatives. It is suitable for various skin diseases that are effective in the treatment of corticosteroids and can reduce inflammation and itching symptoms.

Reference

1:Structures from powders: diflorasone diacetate. Maccaroni E, Giovenzana GB, Palmisano G, Botta D, Volante P, Masciocchi N.Steroids. 2009 Jan;74(1):102-11. doi: 10.1016/j.steroids.2008.09.014. Epub 2008 Oct 18. PMID: 19013475 2:TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Bäumer W, Seegers U, Braun M, Tschernig T, Kietzmann M.Br J Dermatol. 2004 Oct;151(4):823-30. PMID: 15491423 3:Topical diflorasone ointment for treatment of recalcitrant, excessive granulation tissue. Mandrea E.Dermatol Surg. 1998 Dec;24(12):1409-10. No abstract available. PMID: 9865213 4:Comparative efficacy of once-daily flurandrenolide tape versus twice-daily diflorasone diacetate ointment in the treatment of psoriasis. Krueger GG, O/’Reilly MA, Weidner M, Dromgoole SH, Killey FP.J Am Acad Dermatol. 1998 Feb;38(2 Pt 1):186-90. PMID: 9486672 5:Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis. Shupack JL, Jondreau L, Kenny C, Stiller MJ.Dermatology. 1993;186(2):129-32. PMID: 8428041 6:Clobetasol propionate ointment 0.05% versus diflorasone diacetate ointment 0.05% in moderate to severe psoriasis. Jegasothy BV.Int J Dermatol. 1990 Dec;29(10):729-30. No abstract available. PMID: 2269571 7:[Topical treatment of glucocorticoid-sensitive dermatoses with diflorasone diacetate]. Rozman TA.Z Hautkr. 1986 Mar 1;61(5):294, 297-304. German. PMID: 3962411 8:Diflorasone diacetate ointment 0.05 percent in conjunction with UVB and tar in a modified outpatient Goeckerman regimen. Spencer SA, Fenske NA, Bookbinder SA, Vasey FB.Cutis. 1985 Aug;36(2):169-72. PMID: 4028832 9:Liquid chromatographic assay for diflorasone diacetate in cream and ointment formulations. Shaw MC, Vanderwielen AJ.J Pharm Sci. 1984 Nov;73(11):1606-8. PMID: 6520764 10:[Efficacy and safety of topical 0.05% diflorasone diacetate (florone) cream/ointment in patients with acute/chronic dermatitis]. Schneider WD.Z Hautkr. 1984 Oct 1;59(19):1312, 1319-22. German. PMID: 6391003