Chrysophanol

• CAT Number: I003696
• CAS Number: 481-74-3
• Molecular Formula: C15H10O4
• Molecular Weight: 254.2
• Purity: ≥95%
• Target: EGFR[1]
• Solubility: DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
• InChIKey: LQGUBLBATBMXHT-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C(O)=C1)C(C3=C(O)C=CC=C3C2=O)=O

Chrysophanol (CAT: I003696), also known as Chrysophanic acid, is a natural anthraquinone compound. It exhibits inhibitory effects on epidermal growth factor (EGF)-induced phosphorylation of the epidermal growth factor receptor (EGFR). Additionally, Chrysophanol is reported to suppress the activation of the AKT signaling pathway and mTOR/p70S6K pathway. Its ability to modulate these key cellular pathways suggests potential therapeutic applications in conditions related to EGFR signaling dysregulation, such as certain types of cancer. The compound’s mechanisms of action make it an interesting candidate for further exploration in the fields of oncology and targeted therapies.

Reference

1:The effects of chrysophanol on ovalbumin (OVA)-induced chronic lung toxicology by inhibiting Th17 response. Zhang C, Song Y, Wang C, Zhao L, Kang H, Ma X, Wang J, Zhang T, Shumin W, Ma C.Toxicol Mech Methods. 2017 Jun;27(5):327-334. doi: 10.3109/15376516.2015.1053653. PMID: 28399782 2:The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration. Lin FL, Lin CH, Ho JD, Yen JL, Chang HM, Chiou GC, Cheng YW, Hsiao G.Sci Rep. 2017 Jan 23;7:41086. doi: 10.1038/srep41086. PMID: 28112220 Free PMC Article3:Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways. Lim W, Yang C, Bazer FW, Song G.J Cell Physiol. 2017 Feb;232(2):331-339. doi: 10.1002/jcp.25423. Epub 2016 Jun 2. PMID: 27171670 4:Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice. Zhao Y, Fang Y, Li J, Duan Y, Zhao H, Gao L, Luo Y.Neurosci Lett. 2016 Sep 6;630:16-22. doi: 10.1016/j.neulet.2016.07.036. Epub 2016 Jul 20. PMID: 27450437 5:Transcriptomic analysis reveals distinct resistant response by physcion and chrysophanol against cucumber powdery mildew. Li Y, Tian S, Yang X, Wang X, Guo Y, Ni H.PeerJ. 2016 May 17;4:e1991. doi: 10.7717/peerj.1991. eCollection 2016. PMID: 27231648 Free PMC Article6:Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan. Onoda T, Li W, Sasaki T, Miyake M, Higai K, Koike K.J Ethnopharmacol. 2016 Jun 20;186:84-90. doi: 10.1016/j.jep.2016.03.063. Epub 2016 Apr 2. PMID: 27049294 7:Activating Peroxisome Proliferator-Activated Receptors (PPARs): a New Sight for Chrysophanol to Treat Paraquat-Induced Lung Injury. Li A, Liu Y, Zhai L, Wang L, Lin Z, Wang S.Inflammation. 2016 Apr;39(2):928-37. doi: 10.1007/s10753-016-0326-2. PMID: 26920845 8:P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice. Zhang K, Liu J, You X, Kong P, Song Y, Cao L, Yang S, Wang W, Fu Q, Ma Z.Neurosci Lett. 2016 Feb 2;613:60-5. doi: 10.1016/j.neulet.2015.12.043. Epub 2015 Dec 24. PMID: 26724370 9:Application of chrysophanol in zebrafish to reduce dietary introduced lipid and its possible mechanism. Chen K, Wang CQ, Fan YQ, Xie YS, Yin ZF, Xu ZJ, Zhang HL, Cao JT, Wang Y.Int J Clin Exp Med. 2015 Jul 15;8(7):10558-67. eCollection 2015. PMID: 26379845 Free PMC Article10:Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microglia. Lin F, Zhang C, Chen X, Song E, Sun S, Chen M, Pan T, Deng X.Int J Clin Exp Med. 2015 Mar 15;8(3):3447-55. eCollection 2015. PMID: 26064235 Free PMC Article