Chrysin

• CAT Number: R058283
• CAS Number: 480-40-0
• Molecular Formula: C15H10O4
• Molecular Weight: 254.2
• Purity: ≥95%
• Synonyms: 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-2-phenylchromen-4-one; 5,7-Dihydroxyflavone; Crysin; NSC 407436
• Storage: 3 years -20C powder
• InChIKey: RTIXKCRFFJGDFG-UHFFFAOYSA-N

Chrysin(CAT: R058283) is a naturally occurring flavone, a type of flavonoid. It is found in the passion flowers Passiflora caerulea and Passiflora incarnata, and in Oroxylum indicum. It is also found in chamomile, in the mushroom Pleurotus ostreatus, and in honeycomb. At high concentrations, chrysin is reported to be an aromatase inhibitor in vitro. However, studies performed in vivo show that orally administered chrysin does not have clinical activity as an aromatase inhibitor.

Reference

1:Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice. Kang MK, Park SH, Kim YH, Lee EJ, Antika LD, Kim DY, Choi YJ, Kang YH.Acta Pharmacol Sin. 2017 May 15. doi: 10.1038/aps.2017.30. [Epub ahead of print] PMID: 28502979 2:Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide. Gülden M, Appel D, Syska M, Uecker S, Wages F, Seibert H.Food Chem Toxicol. 2017 Apr 27;105:486-497. doi: 10.1016/j.fct.2017.04.035. [Epub ahead of print] PMID: 28458011 3:The Effect of Chrysin Loaded Nanofiber on Wound Healing Process in Male Rat. Mohammadi Z, Sharif Zak M, Majdi H, Seidi K, Barati M, Akbarzadeh A, Latifi AM.Chem Biol Drug Des. 2017 Apr 7. doi: 10.1111/cbdd.12996. [Epub ahead of print] PMID: 28388004 4:Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes. Zheng W, Tao Z, Cai L, Chen C, Zhang C, Wang Q, Ying X, Hu W, Chen H.Inflammation. 2017 Mar 31. doi: 10.1007/s10753-017-0558-9. [Epub ahead of print] PMID: 28364187 5:Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles. Kim KM, Lim HK, Shim SH, Jung J.Int J Nanomedicine. 2017 Mar 9;12:1917-1925. doi: 10.2147/IJN.S132043. eCollection 2017. PMID: 28331315 Free PMC Article6:Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2. Xu D, Jin J, Yu H, Zhao Z, Ma D, Zhang C, Jiang H.J Exp Clin Cancer Res. 2017 Mar 20;36(1):44. doi: 10.1186/s13046-017-0514-4. PMID: 28320429 Free PMC Article7:Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes. Salimi A, Roudkenar MH, Seydi E, Sadeghi L, Mohseni A, Pirahmadi N, Pourahmad J.Cancer Invest. 2017 Mar 16;35(3):174-186. doi: 10.1080/07357907.2016.1276187. Epub 2017 Feb 17. PMID: 28301251 8:Chrysin and baicalin in diabetic nephropathy. Chirumbolo S, Bjørklund G.Environ Toxicol Pharmacol. 2017 Apr;51:156-157. doi: 10.1016/j.etap.2017.02.019. Epub 2017 Feb 22. No abstract available. PMID: 28262431 9:Chrysin induces death of prostate cancer cells by inducing ROS and ER stress. Ryu S, Lim W, Bazer FW, Song G.J Cell Physiol. 2017 Feb 18. doi: 10.1002/jcp.25861. [Epub ahead of print] PMID: 28213961 10:Synthesis, characterization and xanthine oxidase inhibition of Cu(II)-chrysin complex. Lin S, Zeng L, Zhang G, Liao Y, Gong D.Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 5;178:71-78. doi: 10.1016/j.saa.2017.01.056. Epub 2017 Jan 31. PMID: 28167361