Chlorpheniramine Maleate

  • CAT Number: A000748
  • CAS Number: 113-92-8
  • Molecular Formula: C20H23ClN2O4
  • Molecular Weight: 390.86
  • Purity: ≥95%
Inquiry Now

Chlorpheniramine maleate (Cat No.:A000748) is an H1 receptor antagonist and can be used for urticaria, vasodilatory rhinitis, colds, asthma, rhinitis, contact dermatitis, and also for allergies caused by drugs and foods, insect bites and motion sickness, etc.

Catalog Number A000748
CAS Number 113-92-8
Synonyms

Piriton; 113-92-8; Neorestamin; Ibioton; Lorphen

Molecular Formula

C20H23ClN2O4

Purity 95%
Target Histamine Receptor
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey DBAKFASWICGISY-BTJKTKAUSA-N
SMILES CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
Reference

1: Xu W, Deng J, Qian Y, Hou XT, Zhu Z, Zhao M, Shang E, Qian D, Zeng H, Pang H,
Duan J. Simultaneous determination of kaempferol, quercetin, mangiferin, gallic
acid, p-hydroxybenzoic acid, and chlorpheniramine maleate in rat plasma after
oral administration of Mang-Guo-Zhi-Ke Tablets by UHPLC-MS/MS and its application
to pharmacokinetics. Biomed Chromatogr. 2017 Nov 23. doi: 10.1002/bmc.4155. [Epub
ahead of print] PubMed PMID: 29169211.
<br>

2: Farid NF, Naguib IA, Moatamed RS, El Ghobashy MR. TLC-Densitometric and
RP-HPLC Methods for Simultaneous Determination of Dexamethasone and
Chlorpheniramine Maleate in the Presence of Methylparaben and Propylparaben. J
AOAC Int. 2017 Jan 1;100(1):51-58. doi: 10.5740/jaoacint.16-0179. PubMed PMID:
28825536.

<br>
3: Shikino K, Masuyama T, Yamashita T, Ikusaka M. Allergic contact dermatitis
following drug rash due to chlorpheniramine maleate. Clin Case Rep. 2017 Mar
17;5(5):718-719. doi: 10.1002/ccr3.897. eCollection 2017 May. PubMed PMID:
28469883; PubMed Central PMCID: PMC5412794.
<br>

4: de Oliveira GG, Feitosa A, Loureiro K, Fernandes AR, Souto EB, Severino P.
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine
hydrochloride in physical mixtures. Saudi Pharm J. 2017 Jan;25(1):99-103. doi:
10.1016/j.jsps.2016.05.001. Epub 2016 May 7. PubMed PMID: 28223869; PubMed
Central PMCID: PMC5310159.
<br>

5: Acheampong A, Gyasi WO, Darko G, Apau J, Addai-Arhin S. Validated RP-HPLC
method for simultaneous determination and quantification of chlorpheniramine
maleate, paracetamol and caffeine in tablet formulation. Springerplus. 2016 May
14;5:625. doi: 10.1186/s40064-016-2241-2. eCollection 2016. PubMed PMID:
27330891; PubMed Central PMCID: PMC4870525.
<br>

6: Ali A, Ahmed M, Mahmud T, Qadir MA, Nadeem K, Saleem A. Stability-indicating
High-performance Liquid Chromatography Method for Simultaneous Determination of
Aminophylline and Chlorpheniramine Maleate in Pharmaceutical Formulations. Indian
J Pharm Sci. 2015 Sep-Oct;77(5):515-21. PubMed PMID: 26798164; PubMed Central
PMCID: PMC4700702.
<br>

7: Kryvanych O, Bevz N, Harna N, Bevz O. The use of
2,6-dichloroquinone-4chlorimide for quantitative determination of phenylephrine
hydrochloride in combined tablets with paracetamol and chlorpheniramine maleate.
Ceska Slov Farm. 2015 Nov;64(5):216-9. PubMed PMID: 28649822.

<br>
8: Demirel F, Gulec M, Kartal O, Yes&#305;llik S, Baysan A, Musabak U, Sener O.
Allergic reaction to chlorpheniramine maleate. Ann Allergy Asthma Immunol. 2015
Aug;115(2):150-2. doi: 10.1016/j.anai.2015.05.009. PubMed PMID: 26250772.

<br>
9: Zhang F. Physicochemical properties and mechanisms of drug release from
melt-extruded granules consisting of chlorpheniramine maleate and Eudragit FS.
Drug Dev Ind Pharm. 2016;42(4):563-71. doi: 10.3109/03639045.2015.1054832. Epub
2015 Jun 11. PubMed PMID: 26065535.
<br>

10: Ranganathan AT, Chandran CR, Prabhakar P, Lakshmiganthan M, Parthasaradhi T.
Plasma cell gingivitis: treatment with chlorpheniramine maleate. Int J
Periodontics Restorative Dent. 2015 May-Jun;35(3):411-3. doi: 10.11607/prd.2111.
PubMed PMID: 25909529.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!