Chlorambucil (CAS 305-03-3) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.<br />
Chlorambucil(WR-139013; CB-1348) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia.
| Catalog Number | A000140 |
| CAS Number | 305-03-3 |
| Synonyms | 305-03-3; Ambochlorin; Leukeran; Chloroambucil; Chloraminophen |
| Molecular Formula | C14H19Cl2NO2 |
| Purity | 95% |
| Storage | Store at -20C |
| IUPAC Name | 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid |
| InChI | InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) |
| InChIKey | JCKYGMPEJWAADB-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl |
| Reference | 1: Kaur N, Delcros JG, Imran J, Khaled A, Chehtane M, Tschammer N, Martin B, Phanstiel O 4th. A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system. J Med Chem. 2008 Mar 13;51(5):1393-401. doi: 10.1021/jm070794t. Epub 2008 Feb 19. PubMed PMID: 18281932. |
