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Chloroambucil

Chloroambucil

  • CAT Number: A000140
  • CAS Number: 305-03-3
  • Molecular Formula: C14H19Cl2NO2
  • Molecular Weight: 304.21
  • Purity: ≥95%
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Chlorambucil (CAS 305-03-3)&nbsp;is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.<br />
Chlorambucil(WR-139013; CB-1348) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia.

Catalog Number A000140
CAS Number 305-03-3
Molecular Formula

C14H19Cl2NO2

Purity 95%
Storage Store at -20C
IUPAC Name 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
InChI InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey JCKYGMPEJWAADB-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
Reference

1: Kaur N, Delcros JG, Imran J, Khaled A, Chehtane M, Tschammer N, Martin B, Phanstiel O 4th. A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system. J Med Chem. 2008 Mar 13;51(5):1393-401. doi: 10.1021/jm070794t. Epub 2008 Feb 19. PubMed PMID: 18281932.

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