Chelerythrine chloride

• CAT Number: I003429
• CAS Number: 3895-92-9
• Molecular Formula: C₂₁H₁₈NO₄Cl
• Molecular Weight: 383.82
• Purity: ≥95%
• Target: PKC
• Solubility: DMSO: ＞ 3.9 mg/mL
• Storage: Store at -20°C
• IC50: 600 nM
• IUPAC Name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
• InChI: InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
• InChIKey: WEEFNMFMNMASJY-UHFFFAOYSA-M
• SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]

Chelerythrine chloride (Cat.No:I003429) is a natural alkaloid compound derived from various plant sources. It has been studied for its diverse biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. Chelerythrine chloride acts as a potent protein kinase C (PKC) inhibitor, interfering with cellular signaling pathways involved in cell growth, differentiation, and apoptosis. 

Reference

[1]. Chan et al (2003) Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 278 20453.
[2]. Li W, Fan T, Zhang Y, Niu X, Xing W.Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway.Inflammation. 2012 Jul 24.
[3]. Li J, Li B, Wu Y, Shuang S, Dong C, Choi MM.Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep;95:80-5. Epub 2012 Apr 28.
[4]. Pěn?íková K, Kollár P, Müller Závalová V, Táborská E, Urbanová J, Ho?ek J.Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.
[5]. Li GY, Zhong M, Zhou ZD, Zhong YD, Ding P, Huang Y.Formulation optimization of chelerythrine loaded O-carboxymethylchitosan microspheres using response surface methodology.Int J Biol Macromol. 2011 Dec 1;49(5):970-8. Epub 2011 Aug 26.