CGS 21680

• CAT Number: I000745
• CAS Number: 120225-54-9
• Molecular Formula: C23H29N7O6
• Molecular Weight: 499.52
• Purity: ≥95%
• Target: Adenosine Receptor
• Solubility: 10 mM in DMSO
• Storage: 2–8 °C
• IC50: 22 nM
• IUPAC Name: 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
• InChI: InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
• InChIKey: PAOANWZGLPPROA-RQXXJAGISA-N
• SMILES: CCNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O

CGS 21680（Cat No.:I000745） is a potent adenosine A2 receptor agonist that has an IC50 value of 22 nM. It exhibits a 140-fold selectivity over the adenosine A1 receptor. As an A2 receptor agonist, CGS 21680 specifically activates the adenosine A2 receptor subtype, leading to downstream signaling events associated with this receptor. The high selectivity of CGS 21680 for the A2 receptor makes it a valuable tool in studying the functions and mechanisms of A2 receptor-mediated pathways.

Reference

[1]. Hutchison AJ, et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther, 1989, 251(1), 47-55.
[2]. Jarvis MF, et al. [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J Pharmacol Exp Ther, 1989, 251(3), 888-893.
[3]. Phillis JW, et al. The selective adenosine A2 receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res, 1990, 509(2), 328-30.