CGP-71683A

• CAT Number: I006058
• CAS Number: 192322-50-2
• Molecular Formula: C26H30ClN5O2S
• Molecular Weight: 512.069
• Purity: ≥95%
• Target: NPY Receptors
• Solubility: Soluble in DMSO, not in water
• Storage: Desiccate at +4C
• IUPAC Name: N-[[4-[[(4-aminoquinazolin-2-yl)amino]methyl]cyclohexyl]methyl]naphthalene-1-sulfonamide;hydrochloride
• InChI: InChI=1S/C26H29N5O2S.ClH/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24;/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31);1H
• InChIKey: DIQDKUNCSVFGHH-UHFFFAOYSA-N
• SMILES: C1CC(CCC1CNC2=NC3=CC=CC=C3C(=N2)N)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54.Cl

CGP-71683A(CAT: I006058) is a potent and highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y(5) receptor. It is commonly used in research studies focused on obesity and the role of NPY receptors in regulating appetite and energy balance. By specifically blocking the Y(5) receptor, CGP-71683A helps to elucidate the function of this receptor subtype and its potential involvement in the development of obesity and related metabolic disorders. Its selectivity and potency make it a valuable tool in investigating the NPY system and exploring potential therapeutic interventions for obesity.

Reference

1:Preparation of fluorescent nonpeptidic neuropeptide Y receptor ligands: analogues of the quinazoline-type anti-obesity Y5 antagonist CGP 71683A. Li L, Mayer M, Schneider E, Schreiber E, Bernhardt G, Peng S, Buschauer A.Arch Pharm (Weinheim). 2003 Dec;336(12):585-90. PMID: 14677152 2:Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade. Della Zuana O, Sadlo M, Germain M, Félétou M, Chamorro S, Tisserand F, de Montrion C, Boivin JF, Duhault J, Boutin JA, Levens N.Int J Obes Relat Metab Disord. 2001 Jan;25(1):84-94. PMID: 11244462