Cgp 52432

  • CAT Number: I006050
  • CAS Number: 139667-74-6
  • Molecular Formula: C15H24Cl2NO4P
  • Molecular Weight: 384.234
  • Purity: ≥95%
Inquiry Now

Cgp 52432 (CAT: I006050) is a selective antagonist of the gamma-aminobutyric acid type A (GABA-A) receptor. GABA-A receptors are ion channels that mediate inhibitory neurotransmission in the central nervous system. By blocking the activity of GABA-A receptors, Cgp 52432 interferes with the binding of GABA, the main inhibitory neurotransmitter, and disrupts inhibitory signaling in the brain. This antagonist effect on GABA-A receptors may have implications in the modulation of neuronal excitability and the treatment of various neurological and psychiatric disorders.

Catalog Number I006050
CAS Number 139667-74-6

Cgp 52432; Cgp52432; Cgp52432.;Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-

Molecular Formula


Purity 95%
Target GABA Receptor
Solubility Soluble in DMSO, not in water
Storage Desiccate at +4C
IUPAC Name 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid
InChI InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

</br>1:The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep. Jackson GL, Kuehl D.Exp Biol Med (Maywood). 2002 May;227(5):315-20. PMID: 11976401 </br>2:CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Lanza M, Fassio A, Gemignani A, Bonanno G, Raiteri M.Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5. PMID: 8103461

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!