Cgp 52432 (CAT: I006050) is a selective antagonist of the gamma-aminobutyric acid type A (GABA-A) receptor. GABA-A receptors are ion channels that mediate inhibitory neurotransmission in the central nervous system. By blocking the activity of GABA-A receptors, Cgp 52432 interferes with the binding of GABA, the main inhibitory neurotransmitter, and disrupts inhibitory signaling in the brain. This antagonist effect on GABA-A receptors may have implications in the modulation of neuronal excitability and the treatment of various neurological and psychiatric disorders.
| Catalog Number | I006050 |
| CAS Number | 139667-74-6 |
| Synonyms | Cgp 52432; Cgp52432; Cgp52432.;Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)- |
| Molecular Formula | C15H24Cl2NO4P |
| Purity | 95% |
| Target | GABA Receptor |
| Solubility | Soluble in DMSO, not in water |
| Storage | Desiccate at +4C |
| IUPAC Name | 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid |
| InChI | InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20) |
| InChIKey | GJZVQXWEIYRHBE-UHFFFAOYSA-N |
| SMILES | CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O |
| Reference | </br>1:The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep. Jackson GL, Kuehl D.Exp Biol Med (Maywood). 2002 May;227(5):315-20. PMID: 11976401 </br>2:CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Lanza M, Fassio A, Gemignani A, Bonanno G, Raiteri M.Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5. PMID: 8103461 |
