Cgp 52432

  • CAT Number: I006050
  • CAS Number: 139667-74-6
  • Molecular Formula: C15H24Cl2NO4P
  • Molecular Weight: 384.234
  • Purity: ≥95%
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Cgp 52432 (CAT: I006050) is a selective antagonist of the gamma-aminobutyric acid type A (GABA-A) receptor. GABA-A receptors are ion channels that mediate inhibitory neurotransmission in the central nervous system. By blocking the activity of GABA-A receptors, Cgp 52432 interferes with the binding of GABA, the main inhibitory neurotransmitter, and disrupts inhibitory signaling in the brain. This antagonist effect on GABA-A receptors may have implications in the modulation of neuronal excitability and the treatment of various neurological and psychiatric disorders.

Catalog Number I006050
CAS Number 139667-74-6
Synonyms

Cgp 52432; Cgp52432; Cgp52432.;Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-

Molecular Formula

C15H24Cl2NO4P

Purity 95%
Target GABA Receptor
Solubility Soluble in DMSO, not in water
Storage Desiccate at +4C
IUPAC Name 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid
InChI InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)
InChIKey GJZVQXWEIYRHBE-UHFFFAOYSA-N
SMILES CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O
Reference

</br>1:The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep. Jackson GL, Kuehl D.Exp Biol Med (Maywood). 2002 May;227(5):315-20. PMID: 11976401 </br>2:CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Lanza M, Fassio A, Gemignani A, Bonanno G, Raiteri M.Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5. PMID: 8103461

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