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cGAMP

cGAMP

  • CAT Number: I005090
  • CAS Number: 849214-04-6
  • Molecular Formula: C20H24N10O13P2
  • Molecular Weight: 674.4
  • Purity: ≥95%
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Cyclic GMP-AMP (cGAMP)(CAT: I005090) is a second messenger molecule that plays an important role in the immune response to viral infections. It is produced by the enzyme cGAS (cyclic GMP-AMP synthase) when it detects the presence of foreign DNA, such as that from a virus. cGAMP then binds to the protein STING (stimulator of interferon genes), which triggers the production of type I interferons and other cytokines that help fight the infection. cGAMP has also been studied for its potential as an adjuvant in cancer immunotherapy, as it can stimulate the immune system to attack tumor cells.

Catalog Number I005090
CAS Number 849214-04-6
Molecular Formula

C20H24N10O13P2

Purity 95%
Solubility 10 mM in DMSO
Storage -20°C
InChIKey RFCBNSCSPXMEBK-INFSMZHSSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.
<br>[2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150.
<br>[3]. Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18.
<br>[4]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
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