For research use only. Not for therapeutic Use.
Cerdulatinib hydrochloride（Cat No.:I000045）is an oral, dual inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAK1/3), designed to block key signaling pathways in hematologic malignancies and immune disorders. By targeting SYK, it disrupts B-cell receptor signaling, while JAK inhibition suppresses cytokine-driven survival and proliferation signals. This dual activity provides strong anti-tumor and immunomodulatory effects. Preclinical and clinical studies have shown promise in non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, and autoimmune diseases. Cerdulatinib hydrochloride is a valuable compound for studying oncogenic signaling and targeted immunotherapy approaches.
| CAS Number | 1369761-01-2 |
| Synonyms | 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide;hydrochloride |
| Molecular Formula | C20H28ClN7O3S |
| Purity | ≥95% |
| IUPAC Name | 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide;hydrochloride |
| InChI | InChI=1S/C20H27N7O3S.ClH/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14;/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25);1H |
| InChIKey | IYULGYKOHUAYCG-UHFFFAOYSA-N |
| SMILES | CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
