Cephalotaxlen

• CAT Number: I002813
• CAS Number: 24316-19-6
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.36
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol
• InChI: InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
• InChIKey: YMNCVRSYJBNGLD-KURKYZTESA-N
• SMILES: COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5

Cephalotaxine (Cat.No:I002813), also known as Cephalotaxlen, is a natural product derived from the Cephalotaxus tree. It is used in traditional Chinese medicine for its anti-tumor and anti-cancer properties. Cephalotaxine has also shown activity against drug-resistant cancer cells, making it a promising lead compound for drug development. Additionally, it exhibits neuroprotective effects and has potential applications in the treatment of neurodegenerative diseases. However, further research is needed to fully understand the pharmacological properties of cephalotaxine.

Reference

[1]. Wang DZ, et al. Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity Yao Xue Xue Bao. 1992;27(3):178-84.

[2]. Efferth T, et al. Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):56-67.