Cefiderocol - CAS 1225208-94-5

Cefiderocol (CAT: I004918) is a novel cephalosporin antibiotic with a unique mechanism of action. It belongs to the category of siderophore cephalosporins and acts by utilizing iron transport systems to enter bacterial cells. Cefiderocol exhibits potent activity against Gram-negative pathogens, including multidrug-resistant strains such as carbapenem-resistant Enterobacteriaceae (CRE) and extensively drug-resistant Pseudomonas aeruginosa. By binding to penicillin-binding proteins and inhibiting cell wall synthesis, cefiderocol effectively kills bacteria. It has demonstrated efficacy in treating complicated urinary tract infections, hospital-acquired pneumonia, and bloodstream infections caused by difficult-to-treat Gram-negative bacteria.

Catalog Number: I004918

CAS Number: 1225208-94-5

PubChem Substance ID:355153987

Molecular Formula: C30H34ClN7O10S2

Molecular Weight:752.211

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsS-649266; S 649266; S649266; Cefiderocol;(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido]-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidin-1-ium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-e

Property

Molecular Formula: C30H34ClN7O10S2
Molecular Weight752.211
SolubilitySoluble in DMSO, not in water
Purity≥95%
Storage0 - 4 °C for short term or -20 °C for long term
Overview of Clinical Research<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>Cefiderocol is a cell wall inhibitor. The antimicrobial data from the phase III APEKS-NP trial in Gram-negative infections presented at the IDWeek 2020.</span></span></span>

Computed Descriptor

IUPAC Name(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-3-[[1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]pyrrolidin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIInChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChIKeyDBPPRLRVDVJOCL-FQRUVTKNSA-N
SMILESCC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]