CDPPB

• CAT Number: R042549
• CAS Number: 781652-57-1
• Molecular Formula: C23H16N4O
• Molecular Weight: 364.408
• Purity: ≥95%
• Target: GluR
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide
• InChI: InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
• InChIKey: BKUIZWILNWHFHD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4

CDPPB (CAS 781652-57-1)  is a pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic mGluR-5 (glutamate receptor subtype 5). This also exerts anti-psychotic-like effects. It is reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR-5 cells (EC50 = 10 nM. It does not potentiate the activity of other glutamate receptors.

 

Reference

1.Lindsley, Craig W., et al. "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1, 3-diphenyl-1 H-pyrazol-5-yl) benzamides that potentiate receptor function in vivo." Journal of medicinal chemistry 47.24 (2004): 5825-5828.
2.Kinney, Gene G., et al. "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models." Journal of Pharmacology and Experimental Therapeutics 313.1 (2005): 199-206.