CDK9-IN-7

• CAT Number: I018694
• CAS Number: 2369981-71-3
• Molecular Formula: C₂₉H₃₇N₇O₂S
• Molecular Weight: 547.71
• Purity: ≥95%
• IUPAC Name: 7-cyclopentyl-2-[4-(8-isothiocyanatooctanoylamino)anilino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide
• InChI: InChI=1S/C29H37N7O2S/c1-35(2)28(38)25-18-21-19-31-29(34-27(21)36(25)24-10-7-8-11-24)33-23-15-13-22(14-16-23)32-26(37)12-6-4-3-5-9-17-30-20-39/h13-16,18-19,24H,3-12,17H2,1-2H3,(H,32,37)(H,31,33,34)
• InChIKey: LLMKBTGLZJIAMY-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)NC(=O)CCCCCCCN=C=S

CDK9-IN-7 (Cat.No:I018694) is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9). CDK9 is a crucial regulator of transcription and is involved in various cellular processes, including cell proliferation and differentiation. CDK9-IN-7 has been shown to inhibit CDK9-mediated phosphorylation of RNA polymerase II and suppress the growth of cancer cells in vitro and in vivo. It holds promise as a potential therapeutic agent for cancer treatment.

Reference

[1]. Wang X, et al. Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer. Eur J Med Chem. 2019 Jul 25;181:111535.