For research use only. Not for therapeutic Use.
CDK7-IN-2（Cat No.:I044075）is a potent and selective inhibitor of Cyclin-Dependent Kinase 7 (CDK7), a critical regulator of both cell cycle progression and transcription initiation via phosphorylation of RNA polymerase II. By targeting CDK7, this compound disrupts transcriptional regulation and proliferation of cancer cells, particularly those dependent on elevated transcriptional activity, such as in triple-negative breast cancer and acute myeloid leukemia. CDK7-IN-2 is widely used in cancer biology and epigenetic research to study transcriptional addiction, therapeutic resistance, and CDK-targeted drug discovery. It is a valuable tool for developing transcription-targeted therapies.
| CAS Number | 2326428-19-5 |
| Synonyms | [(3S)-1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl] 4-[(5-methyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate |
| Molecular Formula | C26H39N7O3 |
| Purity | ≥95% |
| IUPAC Name | [(3S)-1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl] 4-[(5-methyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate |
| InChI | InChI=1S/C26H39N7O3/c1-18(2)22-16-27-33-23(15-19(3)28-25(22)33)29-20-8-12-31(13-9-20)26(35)36-21-10-14-32(17-21)24(34)7-6-11-30(4)5/h6-7,15-16,18,20-21,29H,8-14,17H2,1-5H3/b7-6+/t21-/m0/s1 |
| InChIKey | GRDAHPJRLCTJNA-BXKJMJEDSA-N |
| SMILES | CC1=NC2=C(C=NN2C(=C1)NC3CCN(CC3)C(=O)O[C@H]4CCN(C4)C(=O)/C=C/CN(C)C)C(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
