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Cdc7-IN-1

Cdc7-IN-1

  • CAT Number: I018768
  • CAS Number: 1402055-25-7
  • Molecular Formula: C₂₁H₁₆ClN₃O₄
  • Molecular Weight: 409.82
  • Purity: ≥95%
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Cdc7-IN-1 (Cat.No:I018768) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death.

Catalog Number I018768
CAS Number 1402055-25-7
Molecular Formula

C₂₁H₁₆ClN₃O₄

Purity 95%
IUPAC Name ethyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylate
InChI InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,25-26H,2H2,1H3/b12-10+
InChIKey MNEODYFHQBZJNQ-ZRDIBKRKSA-N
SMILES CCOC(=O)C1=C(OC(=C1O)/C=C/2C=NC3=C2C=CC=N3)NC4=CC=CC=C4Cl
Reference

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.

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