CD532 hydrochloride

• CAT Number: I045612
• CAS Number: 2926498-81-7
• Molecular Formula: C26H26ClF3N8O
• Molecular Weight: 558.99
• Purity: ≥95%
• Synonyms: 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea;hydrochloride
• InChI: InChI=1S/C26H25F3N8O.ClH/c27-26(28,29)17-6-3-7-20(14-17)33-25(38)32-19-10-8-18(9-11-19)31-24-30-13-12-22(35-24)34-23-15-21(36-37-23)16-4-1-2-5-16;/h3,6-16H,1-2,4-5H2,(H2,32,33,38)(H3,30,31,34,35,36,37);1H
• InChIKey: JEMDMVHTFBVJDO-UHFFFAOYSA-N
• SMILES: C1CCC(C1)C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC=C(C=C4)NC(=O)NC5=CC=CC(=C5)C(F)(F)F.Cl

CD532 hydrochloride (Cat No.: I045612) is a selective small-molecule inhibitor of the anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase implicated in oncogenic signaling, particularly in non-small cell lung cancer and anaplastic large-cell lymphoma. Unlike classical ALK inhibitors, CD532 binds to an inactive conformation of ALK, preventing kinase activation and overcoming resistance mutations. It has been widely used in cancer research to study ALK signaling, resistance mechanisms, and targeted therapy development. The hydrochloride salt enhances solubility, making CD532 suitable for cellular assays.

Reference

[1]. Gustafson WC, et, al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 8;26(3):414-427.
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[2]. Lee JK, et, al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11;29(4):536-547.
[Content Brief]