CCT241533 hydrochloride

• CAT Number: I001665
• CAS Number: 1431697-96-9
• Molecular Formula: C23H28ClFN4O4
• Molecular Weight: 478.94
• Purity: ≥95%
• Target: Chk
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3 nM
• IUPAC Name: 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;hydrochloride
• InChI: InChI=1S/C23H27FN4O4.ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28);1H/t15-,17-;/m1./s1
• InChIKey: LAKJUTZIXHTMPC-SSPJITILSA-N
• SMILES: CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl

CCT241533 hydrochloride（Cat No.:I001665） is a highly potent and selective inhibitor of checkpoint kinase 2 (CHK2). It demonstrates an inhibitory concentration (IC50) of 3 nM and a binding affinity (Ki) of 1.16 nM towards CHK2. By specifically targeting CHK2, CCT241533 hydrochloride disrupts the activity of this protein kinase involved in DNA damage response and cell cycle regulation.

Reference

[1]. Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.
[2]. Caldwell JJ, Welsh EJ, Matijssen C, Anderson VE, Antoni L, Boxall K, Urban F, Hayes A, Raynaud FI, Rigoreau LJ, Raynham T, Aherne GW, Pearl LH, Oliver AW, Garrett MD, Collins I. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.