CCR2 antagonist 4 hydrochloride

• CAT Number: I010802
• CAS Number: 1313730-14-1
• Molecular Formula: C21H22Cl2F3N3O2
• Molecular Weight: 476.32
• Purity: ≥95%
• Synonyms: N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;hydrochloride
• InChI: InChI=1S/C21H21ClF3N3O2.ClH/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25;/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29);1H/t18-;/m1./s1
• InChIKey: PGUQBBISBKGQDC-GMUIIQOCSA-N
• SMILES: C1CN(C[C@@H]1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)CC3=CC=C(C=C3)Cl.Cl

CCR2 antagonist 4 hydrochloride（Cat No.:I010802）is a potent small-molecule inhibitor of the chemokine receptor CCR2, a key mediator of monocyte recruitment and inflammatory signaling. By blocking the CCR2–CCL2 axis, it reduces immune cell infiltration into tissues, thereby attenuating inflammation and tissue damage. This compound has been investigated in preclinical models of autoimmune disease, atherosclerosis, fibrosis, and cancer, where CCR2-driven pathways contribute to pathology. Supplied as a hydrochloride salt for stability and solubility, CCR2 antagonist 4 is a valuable research tool in immunology, oncology, and inflammatory disease research.