For research use only. Not for therapeutic Use.
CCR1 antagonist 9(CAT: I017409) is a potent small-molecule inhibitor of C-C chemokine receptor type 1 (CCR1), a G protein–coupled receptor involved in leukocyte trafficking, inflammation, and autoimmune responses. By blocking CCR1 activity, this compound disrupts chemokine-mediated signaling pathways, reducing recruitment of monocytes and other immune cells to sites of inflammation. CCR1 antagonist 9 has demonstrated potential in preclinical studies for inflammatory and autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and transplant rejection. It serves as a valuable pharmacological tool for investigating CCR1 function, immune modulation, and therapeutic strategies targeting chemokine receptor–mediated inflammatory pathways.
| CAS Number | 1220026-26-5 |
| Synonyms | 1-(4-fluorophenyl)-N-[(2-methylsulfonylpyridin-4-yl)methyl]pyrazolo[3,4-c]pyridine-4-carboxamide |
| Molecular Formula | C20H16FN5O3S |
| Purity | ≥95% |
| IUPAC Name | 1-(4-fluorophenyl)-N-[(2-methylsulfonylpyridin-4-yl)methyl]pyrazolo[3,4-c]pyridine-4-carboxamide |
| InChI | InChI=1S/C20H16FN5O3S/c1-30(28,29)19-8-13(6-7-23-19)9-24-20(27)17-10-22-12-18-16(17)11-25-26(18)15-4-2-14(21)3-5-15/h2-8,10-12H,9H2,1H3,(H,24,27) |
| InChIKey | DCHROQCNJDJPGN-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=NC=CC(=C1)CNC(=O)C2=CN=CC3=C2C=NN3C4=CC=C(C=C4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
