CBS1117

• CAT Number: I015514
• CAS Number: 959245-08-0
• Molecular Formula: C₁₅H₂₀Cl₂N₂O
• Molecular Weight: 315.24
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2,6-dichloro-N-(1-propan-2-ylpiperidin-4-yl)benzamide
• InChI: InChI=1S/C15H20Cl2N2O/c1-10(2)19-8-6-11(7-9-19)18-15(20)14-12(16)4-3-5-13(14)17/h3-5,10-11H,6-9H2,1-2H3,(H,18,20)
• InChIKey: OUZZSIOQTSNTTI-UHFFFAOYSA-N
• SMILES: CC(C)N1CCC(CC1)NC(=O)C2=C(C=CC=C2Cl)Cl

CBS1117（Cat No.:I015514） is a potent inhibitor of influenza A virus entry, specifically targeting the fusion process mediated by the viral hemagglutinin (HA). It exhibits an inhibitory concentration (IC50) of 70 nM against the influenza A virus, strain A/Puerto Rico/8/34 (H1N1). By interfering with HA-mediated fusion, CBS1117 effectively blocks viral entry into host cells, thereby limiting the spread and replication of the influenza virus.

Reference

[1]. Hussein AFA, et al. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782.