For research use only. Not for therapeutic Use.
CB-5339（Cat No.:I044331）is a potent, orally bioavailable inhibitor of valosin-containing protein (VCP/p97), a key regulator of protein homeostasis involved in the ubiquitin-proteasome system. By blocking VCP function, CB-5339 disrupts protein degradation, leading to the accumulation of misfolded proteins and induction of apoptosis in cancer cells. It has shown preclinical efficacy in models of hematologic malignancies and solid tumors, particularly those reliant on proteostasis mechanisms. CB-5339 is under investigation as a therapeutic candidate for targeting protein quality control in cancer, making it a valuable tool in oncology and proteostasis research.
| CAS Number | 1863952-15-1 |
| Synonyms | 1-[4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide |
| Molecular Formula | C24H24N6O |
| Purity | ≥95% |
| IUPAC Name | 1-[4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide |
| InChI | InChI=1S/C24H24N6O/c1-15-13-19-17(21(25)31)9-5-11-20(19)30(15)24-28-22-18(10-6-12-26-22)23(29-24)27-14-16-7-3-2-4-8-16/h2-5,7-9,11,13H,6,10,12,14H2,1H3,(H2,25,31)(H2,26,27,28,29) |
| InChIKey | XDHFSLWWYBVSLN-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=CC=C2N1C3=NC4=C(CCCN4)C(=N3)NCC5=CC=CC=C5)C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
