CAY10398

• CAT Number: R067381
• CAS Number: 193551-00-7
• Molecular Formula: C15H23N3O3
• Molecular Weight: 293.367
• Purity: ≥95%
• Synonyms: MD 85;PX 089274
• Storage: -20°C
• IUPAC Name: 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]benzamide
• InChI: InChI=1S/C15H23N3O3/c1-18(2)13-9-7-12(8-10-13)15(20)16-11-5-3-4-6-14(19)17-21/h7-10,21H,3-6,11H2,1-2H3,(H,16,20)(H,17,19)
• InChIKey: RGWSSTALGUXZMU-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCC(=O)NO

CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 µM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-<wbr></wbr>terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-<wbr></wbr>effective compound for the inhibition of HDAC.

Reference

1.Jung, M.,Hoffmann, K.,Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters 7, 1655-1658 (1997).