CASIN

• CAT Number: I003525
• CAS Number: 425399-05-9
• Molecular Formula: C20H22N2O
• Molecular Weight: 306.409
• Purity: ≥95%
• Target: Cdc42
• Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
• Storage: Store at -20°C
• IUPAC Name: 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
• InChI: InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
• InChIKey: RXIUMAOXORBRCY-UHFFFAOYSA-N
• SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)C4=CC=CC=C4)NCCO

CASIN (CAT: I003525) is a selective inhibitor of the small GTPase Cdc42. Cdc42 is a member of the Rho GTPase family and plays a crucial role in various cellular processes, including cell migration, cytoskeletal reorganization, and cell polarity. By inhibiting Cdc42, CASIN can interfere with these processes and has been studied for its potential in cancer metastasis, inflammation, and other related conditions. It is important to note that CASIN’s selectivity towards Cdc42 distinguishes it from other Rho GTPase inhibitors.

Reference

1:A promising yellow phosphor of Ce3+/Li+ doped CaSiN(2-2δ/3)Oδ for pc-LEDs. Wang XM, Zhang X, Ye S, Jing XP.Dalton Trans. 2013 Apr 14;42(14):5167-73. doi: 10.1039/c3dt32582b. PMID: 23403647 2:Diversity and evolution of the microbial populations during manufacture and ripening of Casín, a traditional Spanish, starter-free cheese made from cow/’s milk. Alegría A, Alvarez-Martín P, Sacristán N, Fernández E, Delgado S, Mayo B.Int J Food Microbiol. 2009 Nov 30;136(1):44-51. doi: 10.1016/j.ijfoodmicro.2009.09.023. Epub 2009 Sep 30. PMID: 19822375 3:Synthesis and structure of alkaline earth silicon nitrides: BaSiN(2), SrSiN(2), and CaSiN(2). Gál ZA, Mallinson PM, Orchard HJ, Clarke SJ.Inorg Chem. 2004 Jun 28;43(13):3998-4006. PMID: 15206881 4:[EXPERIMENT WITH A PLASMIN PREPARATION BY USING THE CASIN SPLITTING TEST: THE ACTION OF PLASMIN-NOVO AND ITS INHIBITION WITH EPSILON-AMINOCAPROIC ACID AND TRASYLOL]. BERGHOFF A, GLATZEL H.Thromb Diath Haemorrh. 1964 Dec 31;12:418-24. German. No abstract available. PMID: 14254701 5:Studies on the influence of minute amounts of fatty acids in bacteriological culture media on bacterial growth (I). Growth-accelerating action of trace amounts of fatty acids in vitamin-free casin acid-hydrolysate on Streptococcus hemolyticus strain S-8. ARAI T, KUWAHARA S.Jpn J Microbiol. 1961 Jul;5:327-35. No abstract available. PMID: 14013520 Free Article