Carnidazole

  • CAT Number: I014286
  • CAS Number: 42116-76-7
  • Molecular Formula: C8H12N4O3S
  • Molecular Weight: 244.27
  • Purity: ≥95%
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Carnidazole (Cat.No:I014286) is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. It is used to treat Trichomonas infection. Inquire Carnidazole online by filling out the inquiry form, we will get back to you within 24 hours!

Catalog Number I014286
CAS Number 42116-76-7
Synonyms

Carnidazole; ME 108; ME-108; ME108; NSC 293873; NSC-293873; NSC293873; R 25831; R-25831; R25831;;O-methyl (2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)carbamothioate

Molecular Formula

C8H12N4O3S

Purity 95%
Solubility Soluble in DMSO
IUPAC Name O-methyl N-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]carbamothioate
InChI InChI=1S/C8H12N4O3S/c1-6-10-5-7(12(13)14)11(6)4-3-9-8(16)15-2/h5H,3-4H2,1-2H3,(H,9,16)
InChIKey OVEVHVURWWTPFC-UHFFFAOYSA-N
SMILES S=C(OC)NCCN1C([N+]([O-])=O)=CN=C1C
Reference

</br>1: Fonzé V, Lambotte R. [Study of carnidazole (R 25831). A new therapeutic agent for vaginal trichomoniasis]. Rev Med Liege. 1979 Oct 1;34(19):811-5. French. PubMed PMID: 549181.</br>2: Chaudhuri P, Drogendijk AC. A double-blind controlled clinical trial of carnidazole and tinidazole in the treatment of vaginal trichomoniasis. Eur J Obstet Gynecol Reprod Biol. 1980 Jun;10(5):325-8. PubMed PMID: 6995193.</br>3: de Armas HN, Peeters OM, Blaton N, Van den Mooter G, De Ridder DJ, Schenk H. Crystal structure of carnidazole form II from synchrotron X-ray powder diffraction: structural comparison with form I, the hydrated form and the low energy conformations in vacuo. J Pharm Sci. 2006 Oct;95(10):2123-36. PubMed PMID: 16892212.</br>4: Notowicz A, Stolz E, de Koning GA. First experiences with single-dose treatment of vaginal trichomoniasis with carnidazole (R 25831). Br J Vener Dis. 1977 Apr;53(2):129-31. PubMed PMID: 322823; PubMed Central PMCID: PMC1045370.</br>5: Jokipii L, Jokipii AM. Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group. Antimicrob Agents Chemother. 1985 Oct;28(4):561-4. PubMed PMID: 4073879; PubMed Central PMCID: PMC180305.</br>6: Munoz E, Castella J, Gutierrez JF. In vivo and in vitro sensitivity of Trichomonas gallinae to some nitroimidazole drugs. Vet Parasitol. 1998 Aug 31;78(4):239-46. PubMed PMID: 9786623.</br>7: Rúbies A, Sans G, Kumar P, Granados M, Companyó R, Centrich F. High-throughput method for the determination of nitroimidazoles in muscle samples by liquid chromatography coupled to mass spectrometry. Anal Bioanal Chem. 2015 Jun;407(15):4411-21. doi: 10.1007/s00216-014-8436-x. Epub 2015 Jan 11. PubMed PMID: 25577363.</br>8: Franssen FF, Lumeij JT. In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica). J Vet Pharmacol Ther. 1992 Dec;15(4):409-15. PubMed PMID: 1487839.</br>9: Cantelli-Forti G, Aicardi G, Guerra MC, Barbaro AM, Biagi GL. Mutagenicity of a series of 25 nitroimidazoles and two nitrothiazoles in Salmonella typhimurium. Teratog Carcinog Mutagen. 1983;3(1):51-63. PubMed PMID: 6132457.</br>10: Rouffaer LO, Adriaensen C, De Boeck C, Claerebout E, Martel A. Racing pigeons: a reservoir for nitro-imidazole-resistant Trichomonas gallinae. J Parasitol. 2014 Jun;100(3):360-3. doi: 10.1645/13-359.1. Epub 2014 Jan 23. PubMed PMID: 24456034.</br>11: Cronly M, Behan P, Foley B, Danaher M, Malone E, Regan L. Survey of 11 nitroimidazole residues in hen and duck eggs from the Irish market. Food Addit Contam Part B Surveill. 2011;4(2):79-87. doi: 10.1080/19393210.2011.573582. Epub 2011 May 23. PubMed PMID: 24785717.</br>12: Boison JO, Asea PA, Matus JL. Validation of a new screening, determinative, and confirmatory multi-residue method for nitroimidazoles and their hydroxy metabolites in turkey muscle tissue by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2012 Aug;4 Suppl 1:130-8. doi: 10.1002/dta.1356. PubMed PMID: 22851370.</br>13: Cronly M, Behan P, Foley B, Malone E, Martin S, Doyle M, Regan L. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Sep;27(9):1233-46. doi: 10.1080/19440049.2010.489579. PubMed PMID: 20597022.</br>14: Van Vaeck L, Van Espen P, Gijbels R, Lauwers W. Structural characterization of drugs and oxygenated metabolites by laser microprobe mass spectrometry (LAMMA). Biomed Environ Mass Spectrom. 1988 Oct;16(1-12):121-9. PubMed PMID: 3242660.</br>15: Iglesias R, Paramá A, Alvarez MF, Leiro J, Sanmartín ML. Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi. Dis Aquat Organ. 2002 Jun 3;49(3):191-7. PubMed PMID: 12113305.</br>16: Cronly M, Behan P, Foley B, Malone E, Regan L. Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1494-500. doi: 10.1016/j.jchromb.2009.03.030. Epub 2009 Mar 25. PubMed PMID: 19345159.</br>17: Cronly M, Behan P, Foley B, Malone E, Regan L. Rapid confirmatory method for the determination of 11 nitroimidazoles in egg using liquid chromatography tandem mass spectrometry. J Chromatogr A. 2009 Nov 13;1216(46):8101-9. doi: 10.1016/j.chroma.2009.04.074. Epub 2009 May 4. PubMed PMID: 19446819.</br>18: Mitrowska K, Antczak M. Development and validation of a liquid chromatography with tandem mass spectrometry method for the determination of nitroimidazole residues in beeswax. J Sep Sci. 2017 Mar;40(5):1158-1166. doi: 10.1002/jssc.201600928. Epub 2017 Feb 8. PubMed PMID: 28054455.</br></br>

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