For research use only. Not for therapeutic Use.
Carmoterol HCl (Cat No.: I004575) is a long-acting β₂-adrenergic receptor agonist (LABA) developed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It enhances bronchodilation by stimulating β₂ receptors in airway smooth muscles, leading to prolonged airway relaxation and improved airflow. Carmoterol exhibits high potency and long duration of action, requiring lower doses than conventional LABAs. Its pharmacokinetic properties make it a promising candidate for respiratory disease management, although further clinical studies are needed to confirm its therapeutic efficacy.
| CAS Number | 137888-11-0 (HCl) |
| Synonyms | TA-2005; TA 2005; TA2005. CHF 4226.01; CHF-4226.; CHF4226.; TA-2005 hydrochloride; Carmoterol HCl; Carmoterol hydrochloride;8-Hydroxy-5-(1-hydroxy-2-(N-(2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril hydrochloride |
| Molecular Formula | C21H25ClN2O4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]-1H-quinolin-2-one;hydrochloride |
| InChI | InChI=1S/C21H24N2O4.ClH/c1-13(11-14-3-5-15(27-2)6-4-14)22-12-19(25)16-7-9-18(24)21-17(16)8-10-20(26)23-21;/h3-10,13,19,22,24-25H,11-12H2,1-2H3,(H,23,26);1H/t13-,19+;/m1./s1 |
| InChIKey | SYCWERNQGSKYAG-QVRIGTRMSA-N |
| SMILES | CC(CC1=CC=C(C=C1)OC)NCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O.Cl |
| Reference | </br> 1: Rossoni G, Manfredi B, Razzetti R, Civelli M, Berti F. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20 |
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