Carmofur

• CAT Number: A000255
• CAS Number: 61422-45-5
• Molecular Formula: C11H16FN3O3
• Molecular Weight: 257.3
• Purity: ≥95%
• Target: DNA Synthesis
• Solubility: >12.2mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• InChIKey: AOCCBINRVIKJHY-UHFFFAOYSA-N
• SMILES: CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.

Reference

1: Domracheva I, Muhamadejev R, Petrova M, Liepinsh E, Gulbe A, Shestakova I,
Duburs G, Arsenyan P. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC)
increases Carmofur stability and in vitro antiproliferative effect. Toxicol Rep.
2015 Jan 27;2:377-383. doi: 10.1016/j.toxrep.2015.01.009. eCollection 2015.
PubMed PMID: 28962371; PubMed Central PMCID: PMC5598257.

2: Miyazaki N, Tabata Y. Anti-tumor activity of carmofur water-solubilized by
lactic acid oligomer-grafted pullulan nanogels. J Nanosci Nanotechnol. 2009
Aug;9(8):4797-804. PubMed PMID: 19928152.

3: Sakamoto J, Hamada C, Rahman M, Kodaira S, Ito K, Nakazato H, Ohashi Y,
Yasutomi M. An individual patient data meta-analysis of adjuvant therapy with
carmofur in patients with curatively resected colon cancer. Jpn J Clin Oncol.
2005 Sep;35(9):536-44. Epub 2005 Sep 9. PubMed PMID: 16155120.

4: Morimoto K, Koh M. Postoperative adjuvant use of carmofur for early breast
cancer. Osaka City Med J. 2003 Dec;49(2):77-83. PubMed PMID: 15179836.

5: Kotake K, Koyama Y, Shida S, Tajima Y, Ishikawa H, Kanazawa K, Miyata M,
Nagamachi Y, Iwasaki Y, Omoto R, Tamakuma S, Kitajima M, Kodaira S; Neo-adjuvant
Chemotherapy for Colorectal Cancer Study Group. [Neo-adjuvant chemotherapy with
carmofur for colorectal cancer–a multi-institutional randomized controlled
study]. Gan To Kagaku Ryoho. 2002 Nov;29(11):1917-24. Japanese. PubMed PMID:
12465390.

6: Fujikawa A, Tsuchiya K, Katase S, Kurosaki Y, Hachiya J. Diffusion-weighted MR
imaging of Carmofur-induced leukoencephalopathy. Eur Radiol. 2001;11(12):2602-6.
Epub 2001 Jun 22. PubMed PMID: 11734966.

7: Ooi A, Ohkubo T, Higashigawa M, Kawasaki H, Kakito H, Kagawa Y, Kojima M,
Sakurai M. Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing
L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed
compound of tegafur and uracil), carmofur and 5/’-deoxy-5-fluorouridine. Biol
Pharm Bull. 2001 Nov;24(11):1329-31. PubMed PMID: 11725974.

8: Osako Y. [A case of reversible carmofur-induced leukoencephalopathy]. No To
Shinkei. 2001 Oct;53(10):986-7. Japanese. PubMed PMID: 11725511.

9: Osterlund P, Elomaa I, Virkkunen P, Joensuu H. A phase I study of raltitrexed
(Tomudex) combined with carmofur in metastatic colorectal cancer. Oncology.
2001;61(2):113-9. PubMed PMID: 11528249.

10: Nakamura T, Ohno M, Tabuchi Y, Kamigaki T, Fujii H, Yamagishi H, Kuroda Y;
Kansai Carmofur Study Group. Optimal duration of oral adjuvant chemotherapy with
Carmofur in the colorectal cancer patients: the Kansai Carmofur Study Group trial
III. Int J Oncol. 2001 Aug;19(2):291-8. PubMed PMID: 11445841.