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Carboxypeptidase G2 (CPG2) Inhibitor

Carboxypeptidase G2 (CPG2) Inhibitor

  • CAT Number: I002462
  • CAS Number: 192203-60-4
  • Molecular Formula: C13H15NO6S
  • Molecular Weight: 313.33
  • Purity: ≥95%
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<p style=/line-height:25px/>Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.</p>

Catalog Number I002462
CAS Number 192203-60-4
Synonyms

(2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid

Molecular Formula

C13H15NO6S

Purity 95%
Target CPG2
Solubility 10 mM in DMSO
Storage Store at -20°C
Reference

<p style=/line-height:25px/>
<br>[1]. Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.

<br>[2]. Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.

<br>[3]. Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.

<br>[4]. Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.

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