Carboxyatractyloside dipotassium

• CAT Number: I014284
• CAS Number: 33286-30-5
• Molecular Formula: C31H44K2O18S2
• Molecular Weight: 846.1243
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Related CAS: 77228-71-8(free acid)
• InChI: InChI=1S/C31H46O18S2.2K/c1-14(2)9-21(33)47-24-23(49-51(42,43)44)22(48-50(39,40)41)18(13-32)46-26(24)45-17-11-29(4)19-6-5-16-10-30(19,25(34)15(16)3)8-7-20(29)31(12-17,27(35)36)28(37)38;;/h14,16-20,22-26,32,34H,3,5-13H2,1-2,4H3,(H,35,36)(H,37,38)(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/t16-,17+,18-,19+,20+,22-,23+,24-,25+,26-,29+,30-;;/m1../s1
• InChIKey: FPJGZZYAZUKPAD-WWJHHVHBSA-L
• SMILES: CC(CC(O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1OS(=O)(O)=O)OS(=O)(O)=O)CO)O[C@H]2C[C@]3([C@@H]4CC[C@@H]5C[C@]4([C@H](C5=C)O)CC[C@@H]3C(C([O-])=O)(C([O-])=O)C2)C)=O)C.[K+].[K+](O)=O)OC(CC(C)C)=O)C[C@@]4(C)[C@@]31[H]

Carboxyatractyloside dipotassium(CAT: I014284) is a toxic compound that is found in certain plants, particularly the cocklebur (Xanthium strumarium). It works by inhibiting the activity of the mitochondrial ADP/ATP carrier, a protein that is responsible for transporting ADP and ATP across the mitochondrial membrane, ultimately leading to a disruption of oxidative phosphorylation and cell death. Due to its toxic effects on mitochondria, carboxyatractyloside dipotassium has been used in research to study mitochondrial function and to develop potential therapies for mitochondrial diseases.

Reference

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