Capsaicin

• CAT Number: I003469
• CAS Number: 404-86-4
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.42
• Purity: ≥95%
• Target: Apoptosis Inducers
• Solubility: DMSO: ≥ 44 mg/mL
• Storage: Store at -20°C
• IC50: 150 uM (MTT assay in FaDu cells) [1]
• InChI: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
• InChIKey: YKPUWZUDDOIDPM-SOFGYWHQSA-N
• SMILES: CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Capsaicin (CAT: I003469) is a naturally occurring compound found in chili peppers. It is responsible for the spicy or hot sensation when consumed. Capsaicin acts as an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, which is involved in pain perception and temperature regulation. It desensitizes sensory nerve endings and can provide temporary relief from pain, particularly in topical applications. Capsaicin creams or patches are commonly used for the management of neuropathic pain, arthritis, and muscle aches. Additionally, capsaicin has been studied for its potential health benefits, including anti-inflammatory properties and promoting weight loss.

Reference

1:Tolling the Bell-cap-sic Bell Against Pain: A Belladonna, Capsaicin, and Aconite Plaster. [No authors listed]Anesthesiology. 2017 Jun;126(6):1064. doi: 10.1097/ALN.0000000000001679. No abstract available. PMID: 28509798 2:Current Understanding of Antiobesity Property of Capsaicin. Narang N, Jiraungkoorskul W, Jamrus P.Pharmacogn Rev. 2017 Jan-Jun;11(21):23-26. doi: 10.4103/phrev.phrev_48_16. Review. PMID: 28503049 Free PMC Article3:Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department: a case series. Dezieck L, Hafez Z, Conicella A, Blohm E, O/’Connor MJ, Schwarz ES, Mullins ME.Clin Toxicol (Phila). 2017 May 11:1-6. doi: 10.1080/15563650.2017.1324166. [Epub ahead of print] PMID: 28494183 4:Influence of Capsaicin on Inflammatory Cytokines Induced by Lipopolysaccharide in Myoblast Cells Under In vitro Environment. Shang K, Amna T, Amina M, Al-Musayeib NM, Al-Deyab SS, Hwang I.Pharmacogn Mag. 2017 Jan;13(Suppl 1):S26-S32. doi: 10.4103/0973-1296.203984. Epub 2017 Apr 7. PMID: 28479722 Free PMC Article5:Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang Y, Zhang Y.Exp Neurol. 2017 May 4. pii: S0014-4886(17)30118-8. doi: 10.1016/j.expneurol.2017.05.001. [Epub ahead of print] PMID: 28479337 6:TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Sadofsky LR, Cantero-Recasens G, Wright C, Valverde MA, Morice AH.J Thorac Dis. 2017 Mar;9(3):839-840. doi: 10.21037/jtd.2017.03.50. No abstract available. PMID: 28449493 Free PMC Article7:Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice. Hu J, Luo H, Jiang Y, Chen P.Oncotarget. 2017 Apr 8. doi: 10.18632/oncotarget.16975. [Epub ahead of print] PMID: 28445156 Free Article8:Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse. Scheich B, Vincze P, Szőke É, Borbély É, Hunyady Á, Szolcsányi J, Dénes Á, Környei Z, Gaszner B, Helyes Z.Eur J Pain. 2017 Apr 25. doi: 10.1002/ejp.1043. [Epub ahead of print] PMID: 28444833 9:The enhanced anti-obesity effect and reduced gastric mucosa irritation of capsaicin-loaded nanoemulsions. Lu M, Cao Y, Ho CT, Huang Q.Food Funct. 2017 Apr 26. doi: 10.1039/c7fo00173h. [Epub ahead of print] PMID: 28443906 10:Somatosensory Profile Changes Evoked by Topical Application of Capsaicin to the Tongue in Healthy Individuals. Honda M, Baad-Hansen L, Iida T, Komiyama O, Kawara M, Svensson P.J Oral Facial Pain Headache. 2016 Spring;31(2):139-146. doi: 10.11607/ofph.1728. PMID: 28437510