Cannabidivarin

• CAT Number: R066294
• CAS Number: 24274-48-4
• Molecular Formula: C19H26O2
• Molecular Weight: 286.4
• Purity: ≥95%
• Synonyms: CBDV;GWP42006
• Target: TRPV1/V2/A1 agonist
• Storage: -20°C
• InChI: InChI=1S/C19H26O2/c1-5-6-14-10-17(20)19(18(21)11-14)16-9-13(4)7-8-15(16)12(2)3/h9-11,15-16,20-21H,2,5-8H2,1,3-4H3/t15-,16+/m0/s1
• InChIKey: REOZWEGFPHTFEI-JKSUJKDBSA-N
• SMILES: OC(C=C(C=C1O)CCC)=C1[C@H]2[C@H](C(C)=C)CCC(C)=C2

Cannabidivarin, also known as CBDV and GWP-42006, is a TRPV1/V2/A1 agonist potentially for treatment of epilepsy.

Reference

1:Development of a Rapid LC-MS/MS Method for the Quantification of Cannabidiol, Cannabidivarin, Δ9-Tetrahydrocannabivarin, and Cannabigerol in Mouse Peripheral Tissues. Piscitelli F, Pagano E, Lauritano A, Izzo AA, Di Marzo V.Anal Chem. 2017 Apr 18;89(8):4749-4755. doi: 10.1021/acs.analchem.7b01094. Epub 2017 Apr 3. PMID: 28343385 2:Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. Iannotti FA, Hill CL, Leo A, Alhusaini A, Soubrane C, Mazzarella E, Russo E, Whalley BJ, Di Marzo V, Stephens GJ.ACS Chem Neurosci. 2014 Nov 19;5(11):1131-41. doi: 10.1021/cn5000524. Epub 2014 Jul 29. PMID: 25029033 3:Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression. Amada N, Yamasaki Y, Williams CM, Whalley BJ.PeerJ. 2013 Nov 21;1:e214. doi: 10.7717/peerj.214. eCollection 2013. PMID: 24282673 Free PMC Article4:Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. Rock EM, Sticht MA, Duncan M, Stott C, Parker LA.Br J Pharmacol. 2013 Oct;170(3):671-8. doi: 10.1111/bph.12322. PMID: 23902479 Free PMC Article5:Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. Hill TD, Cascio MG, Romano B, Duncan M, Pertwee RG, Williams CM, Whalley BJ, Hill AJ.Br J Pharmacol. 2013 Oct;170(3):679-92. doi: 10.1111/bph.12321. PMID: 23902406 Free PMC Article6:Cannabidivarin is anticonvulsant in mouse and rat. Hill AJ, Mercier MS, Hill TD, Glyn SE, Jones NA, Yamasaki Y, Futamura T, Duncan M, Stott CG, Stephens GJ, Williams CM, Whalley BJ.Br J Pharmacol. 2012 Dec;167(8):1629-42. doi: 10.1111/j.1476-5381.2012.02207.x. PMID: 22970845 Free PMC Article7:[Hashish. XX. Cannabidivarin, a new hashish constituent]. Vollner L, Bieniek D, Korte F.Tetrahedron Lett. 1969 Jan;(3):145-7. German. No abstract available. PMID: 5778489