Calycosin

• CAT Number: I002585
• CAS Number: 20575-57-9
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: ≥95%
• Solubility: 1 mg/mL in methanol
• Storage: 3 years -20C powder

Calycosin (CAT: I002585) is a natural isoflavonoid compound found in traditional Chinese medicinal herbs such as Radix astragali (Astragalus membranaceous). It possesses various pharmacological activities and has been studied for its potential therapeutic applications. Calycosin exhibits antioxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. It has been shown to inhibit the production of pro-inflammatory cytokines, reduce oxidative stress, and inhibit tumor cell proliferation. Calycosin also demonstrates estrogenic effects and has been investigated for its potential in hormone-related disorders. Additionally, it shows neuroprotective effects by enhancing neuronal survival and protecting against oxidative damage. Calycosin holds promise as a natural compound with diverse biological activities and potential therapeutic benefits.

Reference

[1]. Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12.

[2]. Chen J, et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8.

[3]. Chen J, et al. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One. 2014 Mar 11;9(3):e91245.

[4]. Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308(2):144-51.