CONTACT US
Home > Reference Standards>Antibiotic> > Calphostin C
Calphostin C

Calphostin C

  • CAT Number: M026227
  • CAS Number: 121263-19-2
  • Molecular Formula: C44H38O14
  • Molecular Weight: 790.774
  • Purity: 95%
Inquiry Now

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides and inhibits cell proliferation and induces apoptosis in vitro.<br />
Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Catalog Number M026227
CAS Number 121263-19-2
Molecular Formula

C44H38O14

Purity 95
Target PKC
Solubility Soluble in DMSO > 10 mM
Storage Desiccate at +4C
Analysis method HPLC
IUPAC Name 1-[3,10-dihydroxy-12-[2-(4-hydroxyphenoxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-4,9-dioxoperylen-1-yl]propan-2-yl benzoate
InChI InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3
InChIKey LSUTUUOITDQYNO-UHFFFAOYSA-N
SMILES CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7
Reference

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. Kobayashi E. et al. , J. Antibiotics, 1989, 42, 1470.&nbsp;<br />
<br />
Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al. , J. Antibiotics, 1989, 42, 1475.&nbsp;<br />
<br />
Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al. , Biochem. Biophys. Res. Commun., 1991, 176, 288.&nbsp;<br />
<br />
Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Begemann M. et al. , Anticancer Res., 1998, 18, 3139.<br />
<br />
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Lepourcelet M. et al. Cancer Cell. 2004, 5, 91.
<p>
&nbsp;</p>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!