Calcipotriol monohydrate

  • CAT Number: I001808
  • CAS Number: 147657-22-5
  • Molecular Formula: C27H42O4
  • Molecular Weight: 430.62
  • Purity: ≥95%
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Calcipotriol monohydrate(CAT: I001808), also known as calcipotriene monohydrate, is a synthetic vitamin D3 analog used to treat psoriasis. Calcipotriol works by binding to vitamin D receptors in skin cells, which helps regulate cell growth and differentiation. This results in a decrease in the production of skin cells and a reduction in inflammation, which is characteristic of psoriasis.

Catalog Number I001808
CAS Number 147657-22-5
Synonyms

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;hydrate

Molecular Formula

C27H42O4

Purity 95%
Target VD/VDR
Solubility 10 mM in DMSO
Storage Store at -20°C
SMILES CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C.O
Reference

1: Molin L. Topical calcipotriol combined with phototherapy for psoriasis. The
results of two randomized trials and a review of the literature. Calcipotriol-UVB
Study Group. Dermatology. 1999;198(4):375-81. Review. PubMed PMID: 10490297.

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2: Mota AV, Correia TM, Lopes JM, Guimar&#227;es JM. Successful treatment of Grover/’s
disease with calcipotriol. Eur J Dermatol. 1998 Jan-Feb;8(1):33-5. Review. PubMed
PMID: 9649669.
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3: Koo J. Calcipotriol/calcipotriene (Dovonex/Daivonex) in combination with
phototherapy: a review. J Am Acad Dermatol. 1997 Sep;37(3 Pt 2):S59-61. Review.
PubMed PMID: 9344187.
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4: Kragballe K. Treatment of psoriasis with calcipotriol and other vitamin D
analogues. J Am Acad Dermatol. 1992 Dec;27(6 Pt 1):1001-8. Review. PubMed PMID:
1479078.

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5: Murdoch D, Clissold SP. Calcipotriol. A review of its pharmacological
properties and therapeutic use in psoriasis vulgaris. Drugs. 1992
Mar;43(3):415-29. Review. PubMed PMID: 1374321.

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