Calcipotriol monohydrate

• CAT Number: I001808
• CAS Number: 147657-22-5
• Molecular Formula: C27H42O4
• Molecular Weight: 430.62
• Purity: ≥95%
• Synonyms: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;hydrate
• Target: VD/VDR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• SMILES: CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C.O

Calcipotriol monohydrate(CAT: I001808), also known as calcipotriene monohydrate, is a synthetic vitamin D3 analog used to treat psoriasis. Calcipotriol works by binding to vitamin D receptors in skin cells, which helps regulate cell growth and differentiation. This results in a decrease in the production of skin cells and a reduction in inflammation, which is characteristic of psoriasis.

Reference

1: Molin L. Topical calcipotriol combined with phototherapy for psoriasis. The
results of two randomized trials and a review of the literature. Calcipotriol-UVB
Study Group. Dermatology. 1999;198(4):375-81. Review. PubMed PMID: 10490297.

2: Mota AV, Correia TM, Lopes JM, Guimarães JM. Successful treatment of Grover/’s
disease with calcipotriol. Eur J Dermatol. 1998 Jan-Feb;8(1):33-5. Review. PubMed
PMID: 9649669.

3: Koo J. Calcipotriol/calcipotriene (Dovonex/Daivonex) in combination with
phototherapy: a review. J Am Acad Dermatol. 1997 Sep;37(3 Pt 2):S59-61. Review.
PubMed PMID: 9344187.

4: Kragballe K. Treatment of psoriasis with calcipotriol and other vitamin D
analogues. J Am Acad Dermatol. 1992 Dec;27(6 Pt 1):1001-8. Review. PubMed PMID:
1479078.

5: Murdoch D, Clissold SP. Calcipotriol. A review of its pharmacological
properties and therapeutic use in psoriasis vulgaris. Drugs. 1992
Mar;43(3):415-29. Review. PubMed PMID: 1374321.