Cabergoline

• CAT Number: I004957
• CAS Number: 81409-90-7
• Molecular Formula: C26H37N5O2
• Molecular Weight: 451.6
• Purity: ≥95%
• Target: Dopamine Receptor
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20℃
• IUPAC Name: (6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
• InChI: InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
• InChIKey: KORNTPPJEAJQIU-KJXAQDMKSA-N
• SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

Cabergoline (Cat.No:I004957) is a medication that works by reducing the levels of prolactin hormone in the body. It is used to treat conditions associated with high prolactin levels, such as prolactin-secreting pituitary tumors, hyperprolactinemia, and Parkinson’s disease. Cabergoline is a dopamine agonist that works by stimulating the dopamine receptors in the brain, which helps to inhibit the production and release of prolactin. 

Reference

1:Template synthesis of maghemite nanoparticle in carboxymethyl cellulose and its application for electrochemical cabergoline sensing. Hasanpour F, Taei M, Banitaba SH, Heidari M.Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:88-93. doi: 10.1016/j.msec.2017.02.128. Epub 2017 Feb 28. PMID: 28482603 2:Cabergoline-related impulse control disorder in an adolescent with a giant prolactinoma. Bulwer C, Conn R, Shankar A, Ferrau F, Kapur S, Ederies A, Korbonits M, Spoudeas HA.Clin Endocrinol (Oxf). 2017 Jun;86(6):862-864. doi: 10.1111/cen.13339. Epub 2017 Apr 24. No abstract available. PMID: 28346715 3:Cabergoline for hyperprolactinemia: getting to the heart of it. Nachtigall LB.Endocrine. 2017 Mar 4. doi: 10.1007/s12020-017-1271-z. [Epub ahead of print] No abstract available. PMID: 28260205 4:Clozapine Treatment for Cabergoline-Induced Psychosis in a Patient With a Giant Prolactinoma. Pérez-Esparza R, Rojas-Guerrero CA, Andino-Rios GG, Arias-Garro P, Ramírez-Bermúdez J, Portocarrero-Ortiz L.J Neuropsychiatry Clin Neurosci. 2017 Feb 27:appineuropsych16110313. doi: 10.1176/appi.neuropsych.16110313. [Epub ahead of print] No abstract available. PMID: 28238271 5:Long-term cardiac (valvulopathy) safety of cabergoline in prolactinoma. Khare S, Lila AR, Patil R, Phadke M, Kerkar P, Bandgar T, Shah NS.Indian J Endocrinol Metab. 2017 Jan-Feb;21(1):154-159. doi: 10.4103/2230-8210.196010. PMID: 28217516 Free PMC Article6:Effect of a single injection of cabergoline at dry off on udder characteristics in high-yielding dairy cows. Bertulat S, Isaka N, de Prado A, Lopez A, Hetreau T, Heuwieser W.J Dairy Sci. 2017 Apr;100(4):3220-3232. doi: 10.3168/jds.2015-10220. Epub 2017 Feb 1. PMID: 28161172 Free Article7:Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial. Sayyah-Melli M, Mobasseri M, Gharabaghi PM, Ouladsahebmadarek E, Rahmani V.Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:257-264. doi: 10.1016/j.ejogrb.2016.11.001. Epub 2016 Dec 23. PMID: 28076829 8:Cabergoline in acromegaly. Kuhn E, Chanson P.Pituitary. 2017 Feb;20(1):121-128. doi: 10.1007/s11102-016-0782-6. Review. PMID: 28025719 9:Remission of acromegaly after treatment withdrawal in patients controlled by cabergoline alone or in combination with octreotide: results from a multicenter study. Casagrande A, Bronstein MD, Jallad RS, Mota JI, Tabet A, Abucham J.J Endocrinol Invest. 2017 May;40(5):523-528. doi: 10.1007/s40618-016-0595-5. Epub 2016 Dec 23. PMID: 28012070 10:Cabergoline for Cushing/’s disease: a large retrospective multicenter study. Ferriere A, Cortet C, Chanson P, Delemer B, Caron P, Chabre O, Reznik Y, Bertherat J, Rohmer V, Briet C, Raingeard I, Castinetti F, Beckers A, Vroonen L, Maiter D, Cephise-Velayoudom FL, Nunes ML, Haissaguerre M, Tabarin A.Eur J Endocrinol. 2017 Mar;176(3):305-314. doi: 10.1530/EJE-16-0662. Epub 2016 Dec 22. PMID: 28007845