CA-074 methyl ester

• CAT Number: I001812
• CAS Number: 147859-80-1
• Molecular Formula: C19H31N3O6
• Molecular Weight: 397.5
• Purity: ≥95%
• Target: Cathepsin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: XGWSRLSPWIEMLQ-YTFOTSKYSA-N

CA-074 methyl ester (CAT: I001812) is a cell-permeable inhibitor of cathepsin B, a lysosomal cysteine protease. It is derived from the parent compound CA-074, but the addition of the methyl ester group enhances its cell permeability. CA-074 methyl ester selectively inhibits cathepsin B activity and has been widely used in research to investigate the role of cathepsin B in various biological processes. By inhibiting cathepsin B, CA-074 methyl ester can modulate cellular processes such as apoptosis, autophagy, inflammation, and tumor progression. Its specific inhibition of cathepsin B makes it a valuable tool for understanding the functions of this protease in both normal physiological and pathological conditions.

Reference

[1]. Xu Y, et al. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016 Jan;120:97-105.

[2]. Patel N, et al. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. J Orthop Res. 2015 Oct;33(10):1474-86.

[3]. Zhang L, et al. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest. 2015 Jan;95(1):65-77.

[4]. Cho K, et al. CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid. Neurosci Lett. 2013 Aug 26;548:222-7.