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C24 Ceramide

C24 Ceramide

  • CAT Number: R001317
  • CAS Number: 34435-05-7
  • Molecular Formula: C42H83NO3
  • Molecular Weight: 650.1
  • Purity: ≥95%
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Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of PLC, appropriately named sphingomyelinase. Lignoceric ceramide (C24:0) is one of the most abundant naturally occurring ceramides. Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing cell-<wbr></wbr>permeable ceramide analogs. A few of the processes regulated by ceramides include apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.

Catalog Number R001317
CAS Number 34435-05-7
Molecular Formula

C42H83NO3

Purity 95%
Storage -20°C
InChIKey ZJVVOYPTFQEGPH-GLIYQNSVSA-N
Reference

<br>1. J. M. Hauser, B. M. Buehrer, and R. M. Bell “Role of ceramide in mitogenesis induced by exogenous sphingoid bases.” Journal of Biological ChemistryVol. 269 pp. 6803, 1994<br>2. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003<br>3. N. S. Radin, “Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria” Bioorganic and Medicinal Chemistry, Vol.11(10) pp. 2123-2142, 2003</br></br></br>

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