C-DIM12

• CAT Number: I002318
• CAS Number: 178946-89-9
• Molecular Formula: C23H17ClN2
• Molecular Weight: 356.85
• Purity: ≥95%
• Target: Nurr1
• Solubility: 10 mM in DMSO
• Storage: Store at RT
• IUPAC Name: 3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole
• InChI: InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
• InChIKey: LTLRXTDMXOFBDW-UHFFFAOYSA-N
• SMILES: ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

C-DIM12 (Cat.No:I002318), also known as bexarotene derivative C, is a synthetic retinoid that has been shown to have potential anticancer properties. It functions as an agonist of the retinoid X receptor (RXR), which plays a role in regulating cell proliferation and differentiation. Studies have shown that C-DIM12 can induce apoptosis and inhibit the growth of various cancer cell lines, making it a promising candidate for further development as an anticancer therapy.

Reference

[1]. De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3/’-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub 2015 Apr 9.

[2]. Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.