BYK204165

• CAT Number: I005346
• CAS Number: 1104546-89-5
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.27
• Purity: ≥95%
• Target: PARP
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4°C
• SMILES: O=C1NC(/C(C2=C1C=CC=C2)=CC3=CC=CN3C)=O

BYK204165(CAT: I005346) is a potent and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP-1). PARP-1 is an enzyme involved in DNA repair, and its inhibition can lead to synthetic lethality in cancer cells with defective DNA repair mechanisms, such as those with BRCA mutations. BYK204165 has shown promising activity in preclinical studies as an anticancer agent by selectively targeting PARP-1 and impairing DNA repair processes, ultimately leading to cell death in cancer cells.

Reference

1: Eltze T, Boer R, Wagner T, Weinbrenner S, McDonald MC, Thiemermann C, Bürkle A, Klein T. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74(6):1587-98. doi: 10.1124/mol.108.048751. Epub 2008 Sep 22. PubMed PMID: 18809672.