Butoconazole nitrate

• CAT Number: A001176
• CAS Number: 64872-77-1
• Molecular Formula: C19H17Cl3N2S.HNO3
• Molecular Weight: 474.79
• Purity: ≥95%
• Storage: Store at -20℃
• IUPAC Name: 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole;nitric acid
• InChI: InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
• InChIKey: ZHPWRQIPPNZNML-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl.[N+](=O)(O)[O-]

Butoconazole nitrate (Cat.No:A001176) is an antifungal medication used to treat vaginal yeast infections. It belongs to the class of imidazole antifungals and works by inhibiting the growth of fungi. Butoconazole is available in various formulations, including creams and suppositories, and is applied directly to the affected area.

Reference

1:Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY.J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):431-6. doi: 10.1007/s11596-014-1296-y. Epub 2014 Jun 18. PMID: 24939312 2:[The statement of Polish Gynecological Society Experts on the treatment of acute vulvovaginal candidiasis with prolonged releasing 2% butoconazole nitrate vaginal cream–state of art in 2008]. Expert Board of Polish Gynecological Society..Ginekol Pol. 2009 Apr;80(4):303-11. Polish. PMID: 19507567 3:An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis. Seidman LS, Skokos CK.Infect Dis Obstet Gynecol. 2005 Dec;13(4):197-206. PMID: 16338779 Free PMC Article4:Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group. Brown D, Henzl MR, Kaufman RH.J Reprod Med. 1999 Nov;44(11):933-8. PMID: 10589403 5:Effect of butoconazole nitrate 2% vaginal cream and miconazole nitrate 2% vaginal cream treatments in patients with vulvovaginal candidiasis. Lappin MA, Brooker DC, Francisco CA, Dorfman J.Infect Dis Obstet Gynecol. 1996;4(6):323-8. PMID: 18476119 Free PMC Article6:Vaginal retention of 2% butoconazole nitrate cream: comparison of a standard and a sustained-release preparation. Weinstein L, Henzel MR, Tsina IW.Clin Ther. 1994 Nov-Dec;16(6):930-4. PMID: 7697689 7:Efficacy of butoconazole nitrate in the treatment of vulvo-vaginal candidiasis compared with clotrimazol and isoconasol. López Fiesco A, Ayala Ruíz A, Romo LM, Delgado MD, Zamora G.Proc West Pharmacol Soc. 1993;36:185-8. No abstract available. PMID: 8378376 8:A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. Ruf H, Vitse M.J Int Med Res. 1990 Sep-Oct;18(5):389-99. PMID: 2257961 9:Vulvovaginal candidosis: comparison of 3-day treatment with 2% butoconazole nitrate cream and 6-day treatment with 1% clotrimazole cream. Hajman AJ.J Int Med Res. 1988 Sep-Oct;16(5):367-75. PMID: 3197914 10:[Butoconazole nitrate in vulvovaginal candidiasis. A comparative study with clotrimazole]. Herrera Nava E, Bervera Castañeda R, Escalona S, Gutiérrez M, Zamora López G.Ginecol Obstet Mex. 1988 May;56:138-43. Spanish. No abstract available. PMID: 3154229