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Butenafine HCl

Butenafine HCl

  • CAT Number: A001112
  • CAS Number: 101827-46-7
  • Molecular Formula: C23H28ClN
  • Molecular Weight: 353.93
  • Purity: ≥95%
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Butenafine HCl is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.<br>Butenafine HCl shows minimum inhibitory concentrations ranging from 0.03–1.0 µg/mL against 30 isolates representing different dermatophyte species. Butenafine shows limited activity against C. albicans and no activity against M. furfur against 10 isolates of two species of yeasts. Butenafine HCl shows activity against β-hemolytic Streptococcus Group A and Corynebacterium but failed to inhibit S. aureus against 25 isolates representing different Gram-positive bacteria species. Butenafine fails to show activity against any of the Gram-negative strains tested.<br>Butenafine (1%, once daily) shows excellent efficacy against dermatophytosis in male hartley strain guinea pigs, and the effect is superior to those of naftifine, tolnaftate, clotrimazole, and bifonazole. Butenafine (1%) exhibits excellent prophylactic efficacy against experimental T. mentagrophytes infection when apply once at 24 or 48 h before infection.

Catalog Number A001112
CAS Number 101827-46-7
Molecular Formula

C23H28ClN

Purity 95%
Target Antibiotic
Solubility >17.6mg/mL in DMSO
Storage 3 years -20C powder

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