BUNGAROTOXIN (beta-)

• CAT Number: P000013
• CAS Number: 65862-89-7
• Molecular Formula: β1 and β2 subunits
• Purity: ≥95%
• Solubility: Well in water, saline and buffer (add saline or buffer after complete solubilization in water).
• Storage: Store at + 4°C In solution, keep at - 20 °C
• Related CAS: 82446-04-6

BUNGAROTOXIN (beta-) is a Phospholipase A2 composed of β1 subunit (120-amino acid) and β2 subunit (61-amino acid) linked by disulfide bridges, from Bungarus multicinctus snake venom


As phospholipas A2, it is a selective inhibitor of the acetylcholine release at the neuromuscular junction.

Reference

– Dreyer et al., /The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals./ J. Physiol. (1987). 386:445

– Chu Chen-Chung et al.,/The non-phospholipase A2 subunit of b-bungarotoxin plays an important role in the phospholipase A2-independent neurotoxic effect: characterization of three isotoxins with a common phospholipase A2 subunit./ Biochem. J. 303(1):171(94

– Rowan et al., /Potassium channel blocking actions of b-bungarotoxin and related toxins on mouse and frog motor nerve terminals./ Br. J. Pharmacol. (1988). 94:839

– Abe et al., /Isolation and characterization of presynaptically acting neurotoxins from the venom of Bungarus snakes./ Eur. J. Biochem. (1977). 80:1

– Strong, /Potassium channel toxins./ Pharmac. Ther. (1990). 46:137