brusatol

• CAT Number: M066293
• CAS Number: 14907-98-3
• Molecular Formula: C26H32O11
• Molecular Weight: 520.531
• Purity: ≥95%
• Synonyms: Yatansin
• Storage: Store at RT
• IUPAC Name: methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-10,15,16-trihydroxy-9,13-dimethyl-3-(3-methylbut-2-enoyloxy)-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate
• InChI: InChI=1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
• InChIKey: ZZZYHIMVKOHVIH-VILODJCFSA-N
• SMILES: CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)C=C(C)C)(OC5)C(=O)OC)O)O)C)O

Brusatol(CAS 14907-98-3) is a natural terpenoid that is capable of inducing a variety of biological effects. 

Reference

1: Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, Toppin HA, Zhang DD. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1433-8. doi: 10.1073/pnas.1014275108. Epub 2011 Jan 4. PubMed PMID: 21205897; PubMed Central PMCID: PMC3029730.
2: Willingham W Jr, Stafford EA, Reynolds SH, Chaney SG, Lee KH, Okano M, Hall IH. Mechanism of eukaryotic protein synthesis inhibition by brusatol. Biochim Biophys Acta. 1981 Jul 27;654(2):169-74. PubMed PMID: 7284376.
3: Hall IH, Lee KH, Eigebaly SA, Imakura Y, Sumida Y, Wu RY. Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells. J Pharm Sci. 1979 Jul;68(7):883-7. PubMed PMID: 458610.
4: Eigebaly SA, Hall IH, Lee KH, Sumida Y, Imakura Y, Wu RY. Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration. J Pharm Sci. 1979 Jul;68(7):887-90. PubMed PMID: 222889.