Broxyquinoline

  • CAT Number: A000812
  • CAS Number: 521-74-4
  • Molecular Formula: C9H5Br2NO
  • Molecular Weight: 302.95
  • Purity: ≥95%
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Broxyquinoline, also known as Dibromoxyquinoline and NSC-1810, is a tetrahydrofolate dehydrogenase inhibitor used to treat vaginitis. Broxyquinoline induces VEGF transcription and shows angiogenic effects, stabilizes HIF-1α, and shows antiprotozoal and antifungal effects in vivo.

Catalog Number A000812
CAS Number 521-74-4
Molecular Formula

C9H5Br2NO

Purity 95%
Target Tetrahydrofolate Dehydrogenase Inhibitor
Storage -20°C
InChI InChI=1S/C9H5Br2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKey ZDASUJMDVPTNTF-UHFFFAOYSA-N
SMILES C1=CC2=C(C(=C(C=C2Br)Br)O)N=C1
Reference

1: Swain R, Bapna JS. Impairment of exercise tolerance due to
broxyquinoline-brobenzoxaldine combination. Hum Toxicol. 1986 Jan;5(1):63-4.
PubMed PMID: 3081430.
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2: Swain R, Bapna JS, Das AK, Chandrasekar S, Swaminathan RP, Bosco B, Veliath S,
Thombre DP. A study on the neurotoxicity of broxyquinoline and brobenzoxaldine
combination in therapeutic doses. Hum Toxicol. 1986 Jan;5(1):35-41. PubMed PMID:
3081428.
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3: Hazra SK, Ghosh S, Kundu SK, Chaudhuri S. Therapeutic trial of a combination
of broxyquinoline and brobenzoxaldine in the treatment of leprosy. Lepr India.
1979 Oct;51(4):505-10. PubMed PMID: 118304.

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4: Edibam BM. Comparative study of the efficacy of chloramphenicol and a
combination of chloramphenicol, broxyquinoline and brobanzoxaldine in the
treatment of enteric fever. Indian Pediatr. 1975 Jul;12(7):587-91. PubMed PMID:
810421.

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5: Sharma CS. Letter: Effect of broxyquinoline and broxaldine in leprosy. Lancet.
1975 Feb 15;1(7903):405. PubMed PMID: 46561.
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6: Rao SR, Rajyalaxmi K, Murthy KJ, Chandrasekhar VP. Anti-fungal activity of
broxyquinoline and brobenzoxaldine. J Assoc Physicians India. 1973
Mar;21(3):295-8. PubMed PMID: 4792779.

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7: Shah AP, Phatak AT. A clinical trial of broxyquinoline–brobenzoxalidine in
childhood diarrhoea. Indian J Pediatr. 1973 Mar;40(302):83-92. PubMed PMID:
4585812.

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8: Bengtsson K, Vikrot O. [Retrograde amnesia after broxyquinoline intake].
Lakartidningen. 1972 Jun 12;69:Suppl 2:14-6. Swedish. PubMed PMID: 4645695.
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9: Majumdar M, Majumdar H. Broxyquinoline and brobenzoxaldine with belladonna in
childhood diarrhoeas. Indian Pediatr. 1971 Feb;8(2):65-7. PubMed PMID: 5560455.

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10: Manchanda SS, Grover L, Bhushan S, Lal H. Broxyquinoline and brobenzoxalidine
suspension (Intestopan-AI 307) in childhood diarrhoea. A clinical trial on 533
children. Indian J Pediatr. 1970 May;37(268):177-84. PubMed PMID: 4933138.

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