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BREVETOXIN PbTx-1

BREVETOXIN PbTx-1

  • CAT Number: T000080
  • CAS Number: 98112-41-5
  • Molecular Formula: C49H70O13
  • Molecular Weight: 867.086
  • Purity: ≥95%
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BREVETOXIN PbTx-1(cas 98112-41-5) is an activator of voltage-sensitive Na+ channels
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Cyclic polyether<!–C<sub>49</sub>H<sub>70</sub>O<sub>13</sub>–>, from the microorganism <i>Ptychodiscus brevis</i>.<br />
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<span style=/font-size:10.0pt;font-family:;/>A neurotoxin that binds to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as neurotoxic shellfish poisoning<br />
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Catalog Number T000080
CAS Number 98112-41-5
Molecular Formula

C49H70O13

Purity 95%
Solubility In acetone, ethyl acetate, methanol (decomp.), ethanol (decomp.), water
Storage Brevetoxins are unusually stable materials in the dry state under vacuum. It is recommended that PbTx-1 be stored at -20°C in its original unopened vial until use. Once opened, PbTx-1 should be dissolved in an appropriate solvent like dry acetone,
InChI InChI=1S/C49H70O13/c1-26-17-36-39(22-45(52)58-36)57-44-21-38-40(62-48(44,4)23-26)18-28(3)46-35(55-38)11-7-6-10-31-32(59-46)12-8-14-34-33(54-31)13-9-15-43-49(5,61-34)24-42-37(56-43)20-41-47(60-42)30(51)19-29(53-41)16-27(2)25-50/h6-8,14,25-26,28-44,46-47,51H,2,9-13,15-24H2,1,3-5H3/b7-6-,14-8-/t26-,28+,29-,30+,31-,32+,33+,34-,35+,36+,37+,38-,39-,40+,41-,42-,43-,44+,46-,47+,48-,49+/m1/s1
InChIKey MGVIMUPHKPHTKF-HQUFVKSZSA-N
SMILES CC1CC2C(CC(=O)O2)OC3CC4C(CC(C5C(O4)CC=CCC6C(O5)CC=CC7C(O6)CCCC8C(O7)(CC9C(O8)CC2C(O9)C(CC(O2)CC(=C)C=O)O)C)C)OC3(C1)C
Reference

– Shimizu et al., <i>J. Am. Chem. Soc.</i>(1986) 108:514<br />
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– Catterall et al., Toxicon (1985). 23:497<br />
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– Trainer et al., <i>ACS, Symposium series</i>(1990) 418:166<br />
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