For research use only. Not for therapeutic Use.
BRD5648 (CAT: I017224) is the inactive enantiomer of BRD0705, a potent, paralog-selective, and orally active GSK3α inhibitor. Unlike its active counterpart, BRD5648 shows no inhibitory activity on GSK3α or GSK3β and does not alter enzyme phosphorylation or stabilize β-catenin protein levels. It serves as a negative control compound in studies investigating BRD0705-mediated signaling and pharmacological effects. The availability of BRD5648 alongside BRD0705 enables rigorous evaluation of target selectivity, off-target effects, and enantiomer-specific activity. This makes BRD5648 a critical reference tool for research on glycogen synthase kinase biology, leukemia (AML), and therapeutic target validation.
| CAS Number | 2056261-42-6 |
| Synonyms | (4R)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| Molecular Formula | C20H23N3O |
| Purity | ≥95% |
| IUPAC Name | (4R)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| InChI | InChI=1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)/t20-/m1/s1 |
| InChIKey | NCKLQXXBRWCYMA-HXUWFJFHSA-N |
| SMILES | CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
