Indirubin

• CAT Number: I003680
• CAS Number: 479-41-4
• Molecular Formula: C16H10N2O2
• Molecular Weight: 262.3
• Purity: ≥95%
• Target: GSK-3
• Solubility: DMSO 40 mg/ml
• Storage: -20°C
• IUPAC Name: 2-(2-hydroxy-1H-indol-3-yl)indol-3-one
• InChI: InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
• InChIKey: JNLNPCNGMHKCKO-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O

Indirubin（Cat No.:I003680） is a new type of bisindole antineoplastic drug that has a therapeutic effect on chronic myelogenous leukemia (CML). Indirubin has anti-cancer effects and is clinically used in the treatment of chronic myelogenous leukemia.

Reference

1:Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice. Qi T, Li H, Li S.Oncotarget. 2017 May 2. doi: 10.18632/oncotarget.17560. [Epub ahead of print] PMID: 28525368 2:Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells. Ndolo KM, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY.Immune Netw. 2017 Apr;17(2):110-115. doi: 10.4110/in.2017.17.2.110. Epub 2017 Apr 20. PMID: 28458622 Free PMC Article3:Induction of cell death in pancreatic ductal adenocarcinoma by indirubin 3/’-oxime and 5-methoxyindirubin 3/’-oxime in vitro and in vivo. Sano M, Ichimaru Y, Kurita M, Hayashi E, Homma T, Saito H, Masuda S, Nemoto N, Hemmi A, Suzuki T, Miyairi S, Hao H.Cancer Lett. 2017 Jul 1;397:72-82. doi: 10.1016/j.canlet.2017.03.031. Epub 2017 Mar 24. PMID: 28347789 4:Indirubin inhibits the migration, invasion, and activation of fibroblast-like synoviocytes from rheumatoid arthritis patients. Huang M, Wang L, Zeng S, Qiu Q, Zou Y, Shi M, Xu H, Liang L.Inflamm Res. 2017 May;66(5):433-440. doi: 10.1007/s00011-017-1027-5. Epub 2017 Mar 6. PMID: 28265680 5:Indirubin Treatment of Lipopolysaccharide-Induced Mastitis in a Mouse Model and Activity in Mouse Mammary Epithelial Cells. Lai JL, Liu YH, Peng YC, Ge P, He CF, Liu C, Chen YY, Guo AZ, Hu CM.Mediators Inflamm. 2017;2017:3082805. doi: 10.1155/2017/3082805. Epub 2017 Feb 1. PMID: 28255203 Free PMC Article6:The Indirubin Derivative 6-Bromoindirubin-3/’-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects. Tsakiri EN, Gaboriaud-Kolar N, Iliaki KK, Tchoumtchoua J, Papanagnou ED, Chatzigeorgiou S, Tallas KD, Mikros E, Halabalaki M, Skaltsounis AL, Trougakos IP.Antioxid Redox Signal. 2017 May 16. doi: 10.1089/ars.2016.6910. [Epub ahead of print] PMID: 28253732 7:Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration. Ye B, Xiong X, Deng X, Gu L, Wang Q, Zeng Z, Gao X, Gao Q, Wang Y.Pharm Biol. 2017 Dec;55(1):673-679. PMID: 27981893 8:Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways. Lai JL, Liu YH, Liu C, Qi MP, Liu RN, Zhu XF, Zhou QG, Chen YY, Guo AZ, Hu CM.Inflammation. 2017 Feb;40(1):1-12. doi: 10.1007/s10753-016-0447-7. PMID: 27718095 9:Indirubin-3/’-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation. Zhang SG, Wang XS, Zhang YD, Di Q, Shi JP, Qian M, Xu LG, Lin XJ, Lu J.Neural Regen Res. 2016 Jun;11(6):988-93. doi: 10.4103/1673-5374.184500. PMID: 27482230 Free PMC Article10:Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Yu J, Zheng J, Lin J, Jin L, Yu R, Mak S, Hu S, Sun H, Wu X, Zhang Z, Lee M, Tsim W, Su W, Zhou W, Cui W, Han Y, Wang Q.Cell Mol Neurobiol. 2017 May;37(4):655-664. doi: 10.1007/s10571-016-0402-z. Epub 2016 Jul 13. PMID: 27412761