Brassinolide

• CAT Number: I004718
• CAS Number: 72962-43-7
• Molecular Formula: C28H48O6
• Molecular Weight: 480.7
• Purity: ≥95%
• Synonyms: (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-((2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl)-5,6-dihydroxy-7a,9a-dimethyltetradecahydro-1H-benzo[c]indeno[5,4-e]oxepin-3(12bH)-one
• Target: Apoptosis Inducers
• Solubility: DMSO: ≥ 5.2 mg/mL
• Storage: Store at -20°C
• InChIKey: IXVMHGVQKLDRKH-KNBKMWSGSA-N

Brassinolide is a plant sterol first isolated from pollen of rape (Brassica napus L.), Brassinolide could promote stem elongation and cell division.IC50 Value:Target:in vitro: Caspase-3 activity was obviously increased after brassinolide treatment. Western blot studies indicated that treatment with brassinolide triggered a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2 [1]. After treatment of brassinolide under the concentration of 0.001 – 10.0 microg x mL(-1), the resistance of CCRF-VCR was reversed partly with the reversing folds respectively as 4.4 – 11.6 [2]. After brassinolide treatment, the expression of p53 in CCRF-VCR cells restored to the level of sensitive cells.in vivo: After oral administration of Brassinolide for consecutive 7 days(once every day),the levels of blood glucose were evaluated on the day 0 and the day 7 [3].Clinical trial: N/A

Reference

[1]. Wu YD, Lou YJ. Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells. Pharmazie. 2007 May;62(5):392-5.
[2]. Xian LJ, Li YQ, Liu RY, Reversing effect of brassinolide on multidrug resistance of-CCRF-VCR1000 cells and a preliminary investigation on its mechanisms. Yao Xue Xue Bao. 2005 Feb;40(2):117-21.
[3]. CHEN Shi-ping,HE Jia,WANG Qi-jing, Effect of Brassinolide on Levels of Blood Glucose in Alloxan-induced Diabetes Rats.